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Heat Shock Proteins, Unfolded Protein Response Chaperones and Alzheimer’s Disease

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Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection

Part of the book series: Heat Shock Proteins ((HESP,volume 3))

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Abstract

Molecular chaperones interact with cellular proteins to ensure proper folding and transport between or into organelles. They also associate with mature proteins that have unfolded (and become prone to aggregation) because of an environmental insult such as heat shock. There is a large body of evidence that protein quality control mechanisms involving the HSP family of molecular chaperones, as well as proteasomal and lysosomal functions, become impaired with aging and contribute to a variety of neurodegenerative diseases. Promising therapeutic approaches tested in animal models of Parkinson’s and polyglutamine diseases include the up-regulation of molecular chaperones to prevent protein misfolding and aggregation and to facilitate clearance mechanisms. In spite of a slow start, the role of molecular chaperones in Alzheimer’s disease is increasingly being elucidated at the molecular level. This chapter summarizes the nature of the cellular stress response that is induced in Alzheimer’s disease and examines current research related to the function of molecular chaperones in the cellular metabolism of tau and β-amyloid peptide

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Authors and Affiliations

  1. Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY, USA

    Jordi Magrané

  2. Department of Neurology, Caritas St Elizabeth’s Medical Center, Tufts University School of Medicine, Boston, MA, USA

    Henry W. Querfurth

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  1. Jordi Magrané
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  2. Henry W. Querfurth
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Editors and Affiliations

  1. Effie and Wofford Cain Centennial Endowed Chair in Clinical Pathology, Chief, Division of Investigative Pathology, Scott & White Memorial Hospital and Clinic and The Texas A&M Health Science Center College of Medicine, Temple, Texas, U.S.A

    Alexzander A.A. Asea

  2. Department of Biological Sciences, Center for the Neurobiology of Stress, University of Toronto at Scarborough, Toronto, ON, Canada

    Ian R. Brown

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© 2008 Springer Science+Business Media B.V.

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Magrané, J., Querfurth, H.W. (2008). Heat Shock Proteins, Unfolded Protein Response Chaperones and Alzheimer’s Disease. In: Asea, A.A., Brown, I.R. (eds) Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection. Heat Shock Proteins, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8231-3_2

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