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Release of Heat Shock Proteins and their Effects When in the Extracellular Space in the Nervous System

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Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection

Part of the book series: Heat Shock Proteins ((HESP,volume 3))

Abstract

The ability of heat shock proteins (Hsps) to make cells more resistant to most types of metabolic stress has great implications for all post-mitotic cells, especially those of the nervous system. Preventing the loss of neurons is a more parsimonious approach to treatment of injury and disease than is replacement because of the difficulty in reconstructing the complex architecture of the nervous system, the basis for its function storage of information. The discoveries that the 70,kD Hsps are released and that neurons can take them up from the extracellular fluid provides a rationale to investigate how to use them to rescue injured neurons teetering between life and death. We present some of the history behind those discoveries and review the current understanding of the release and uptake of the 70,kD Hsps, discussing the distinct significance these observations have for neurons and some hypotheses about how extracellular Hsps protect neurons from potentially lethal injuries

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Authors and Affiliations

  1. Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, NC, USA

    Michael Tytell, Mac B. Robinson & Carolanne E. Milligan

  2. Program in Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC, USA

    Michael Tytell & Carolanne E. Milligan

  3. Molecular Genetics and Genomics Program, Wake Forest University School of Medicine, Winston-Salem, NC, USA

    Mac B. Robinson & Carolanne E. Milligan

Authors
  1. Michael Tytell
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  2. Mac B. Robinson
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  3. Carolanne E. Milligan
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Editors and Affiliations

  1. Effie and Wofford Cain Centennial Endowed Chair in Clinical Pathology, Chief, Division of Investigative Pathology, Scott & White Memorial Hospital and Clinic and The Texas A&M Health Science Center College of Medicine, Temple, Texas, U.S.A

    Alexzander A.A. Asea

  2. Department of Biological Sciences, Center for the Neurobiology of Stress, University of Toronto at Scarborough, Toronto, ON, Canada

    Ian R. Brown

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© 2008 Springer Science+Business Media B.V.

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Tytell, M., Robinson, M.B., Milligan, C.E. (2008). Release of Heat Shock Proteins and their Effects When in the Extracellular Space in the Nervous System. In: Asea, A.A., Brown, I.R. (eds) Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection. Heat Shock Proteins, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8231-3_13

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