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Stable Valence Anions of Nucleic Acid Bases and DNA Strand Breaks Induced by Low Energy Electrons

  • Chapter
Radiation Induced Molecular Phenomena in Nucleic Acids

Part of the book series: Challenges and Advances In Computational Chemistry and Physics ((COCH,volume 5))

abstract

The last decade has witnessed immense advances in our understanding of the effects of ionizing radiation on biological systems. As the genetic information carrier in biological systems, DNA is the most important species which is prone to damage by high energy photons. Ionizing radiations destroy DNA indirectly by forming low energy electrons (LEEs) as secondary products of the interaction between ionizing radiation and water. An understanding of the mechanism that leads to the formation of single and double strand breaks may be important in guiding the further development of anticancer radiation therapy. In this article we demonstrate the likely involvement of stable nucleobases anions in the formation of DNA strand breaks – a concept which the radiation research community has not focused on so far. In Section refch21:sec21.1 we discuss the current status of studies related to the interaction between DNA and LEEs. The next section is devoted to the description of proton transfer induced by electron attachment to the complexes between nucleobases and various proton donors – a process leading to the strong stabilization of nucleobases anions. Then, we review our results concerning the anionic binary complexes of nucleobases with particular emphasize on the GC and AT systems. Next, the possible consequences of interactions between DNA and proteins in the context of electron attachment are briefly discussed. Further, we focus on existing proposal of single strand break formation in DNA. Ultimately, open questions as well perspectives of studies on electron induced DNA damage are discussed

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  1. Faculty of Chemistry, University of Gdańsk, Sobieskiego 18, 80-952 Gdańsk, Poland

    Janusz Rak, Kamil Mazurkiewicz, Monika Kobyłecka, Piotr Storoniak, Maciej Haranczyk, Iwona DĄbkowska & Maciej Gutowski

  2. Lehrstuhl für Theoretische Chemie Institut für Physikalische Chemie, Universität Karlsruhe (TH), D-76128 Karlsruhe, Germany

    Rafał A Bachorz

  3. Chemistry-School of Engineering and Physical Sciencs, Heriot-Watt University, Edinburgh, EH14 4AS, UK

    Maciej Gutowski

  4. Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA

    Dunja Radisic, Sarah T. Stokes, Soren N. Eustis, Di Wang, Xiang Li, Yeon Jae Ko & Kit H. Bowen

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  1. Department of Chemistry, Jackson State University, 1325 J. R. Lynch Street, Jackson, MS 39217, USA

    Manoj K. Shukla  & Jerzy Leszczynski  & 

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Rak, J. et al. (2008). Stable Valence Anions of Nucleic Acid Bases and DNA Strand Breaks Induced by Low Energy Electrons. In: Shukla, M.K., Leszczynski, J. (eds) Radiation Induced Molecular Phenomena in Nucleic Acids. Challenges and Advances In Computational Chemistry and Physics, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8184-2_21

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