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The microsporidia genome: Living with minimal genes as an intracellular eukaryote

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Opportunistic Infections: Toxoplasma, Sarcocystis, and Microsporidia

Part of the book series: World Class Parasites ((WCPA,volume 9))

Abstract

Encephalitozoon cuniculi is a mammal-infecting microsporidian harbouring an extremely reduced nuclear genome (2.9 Mbp). Following its complete sequencing, gene annotation has revealed possible transport and metabolic pathways in the parasite. A clathrin-independent route of endocytosis is predicted. Anaerobic glycolysis and pentose-phosphate pathway may account for generation of ATP and reducing power, respectively, but the fates of pyruvate and NADH remain to be explored. A mevalonate pathway may produce geranylgeranyl and dolichyl groups, not sterols. Although the microsporidian Golgi apparatus is unstacked, several encoded proteins are specific of cis and trans Golgi compartments. Encephalitozoon cuniculi should be unable to perform Nlinked glycosylation, a unique case among eukaryotes.

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  1. Laboratoire de Parasitologie moléculaire et cellulaire, LBP, UMR CNRS 6023, Université Blaise Pascal - Clermont-Ferrand, 63177, Aubière Cedex, France

    Christian P. Vivarès & Guy Méténier

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  1. Christian P. Vivarès
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  2. Guy Méténier
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  1. Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia, USA

    David S. Lindsay

  2. Albert Einstein College of Medicine, Bronx, New York, USA

    Louis M. Weiss

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© 2004 Kluwer Academic Publishers

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Vivarès, C.P., Méténier, G. (2004). The microsporidia genome: Living with minimal genes as an intracellular eukaryote. In: Lindsay, D.S., Weiss, L.M. (eds) Opportunistic Infections: Toxoplasma, Sarcocystis, and Microsporidia. World Class Parasites, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4020-7846-0_12

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  • DOI: https://doi.org/10.1007/978-1-4020-7846-0_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4020-7814-9

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