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Natural killer T (NKT) cells: Immunophenotype, functional characteristics and significance in clinical practice

  • Olga V. Lebedinskaya
  • Nelly K. Akchmatova
  • Irina O. Chikileva
  • Irina Zh. Shubina
  • Mikhail V. Kiselevsky

Abstract

Natural killer T cells are lymphocytes that express both T-cell and natural killer-cell markers. Natural killer T cells are found in parenchymal organs such as liver, lungs, spleen etc and a small number are found in peripheral blood. Natural killer T cells comprise a significant part of leukocyte infiltrates that occur in liver and other organs of patients with cancer or infectious diseases. These cells have a large impact on the functional activity of effectors of anti-tumor and anti-infectious immunity.

Keywords

NKT cells IL-12 cytokines immunophenotype 

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© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Olga V. Lebedinskaya
    • 1
  • Nelly K. Akchmatova
    • 2
  • Irina O. Chikileva
    • 3
  • Irina Zh. Shubina
    • 3
  • Mikhail V. Kiselevsky
    • 3
  1. 1.Department of Histology Embryology and CytologyEA Vagner Perm Medical AcademyPermRussia
  2. 2.II Metchnikov Research Institute of Vaccines and Serum Laboratory of Therapeutic Vaccines MoscowRussia
  3. 3.Laboratory of Cell ImmunityNN Blokhin Russian Cancer Research Center RAMSMoscowRussia

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