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Gadolinium Endohedral Metallofullerene-Based MRI Contrast Agents

  • Robert D. Bolskar
Chapter
Part of the Carbon Materials: Chemistry and Physics book series (CMCP, volume 1)

Abstract

With the ability to encapsulate and carry the highly paramagnetic Gd3+ ion, gadolinium endohedral metallofullerenes or “gadofullerenes” are being explored as alternatives to the chelate complexes that are currently used for contrast-enhanced magnetic resonance imaging (MRI). Reviewed here are the various water-soluble derivatives of the gadofullerenes Gd@C82, Gd@C60, and Gd3N@C80 that have been investigated as MRI contrast agents. The water proton r1 relaxivities of gadofullerenes can be more than an order of magnitude higher than those of clinically used chelate agents. Gadofullerene relaxivity mechanisms have been studied, and multiple factors are found to contribute to their high relaxivities. In vitro and in vivo T 1 -weighted MRI tests of gadofullerene derivatives have shown their utility as bright image-enhancing agents. The gadofullerene MRI contrast agents are a promising new and unique style of gadolinium carrier for advanced imaging applications, including cellular and molecular imaging.

Keywords

Metallofullerene endohedral gadolinium magnetic resonance imaging contrast agent relaxivity cellular imaging molecular imaging 

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Copyright information

© Springer Science + Business Media B.V 2008

Authors and Affiliations

  • Robert D. Bolskar
    • 1
  1. 1.TDA Research Inc.Wheat RidgeUSA

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