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Effects of Photoexcited Fullerene C60-Composites in Normal and Transformed Cells

  • S. V. Prylutska
  • I. I. Grynyuk
  • O. P. Matyshevska
  • A. A. Golub
  • A. P. Burlaka
  • Yu. I. Prylutskyy
  • U. Ritter
  • P. Scharff
Chapter
Part of the Carbon Materials: Chemistry and Physics book series (CMCP, volume 1)

Abstract

The supramolecular composites containing fullerenes C60 immobilized at nanosilica were used for the design of the molecular systems that can be an effective agent in cancer photodynamic therapy (PDT). In particular, it was shown that photoexcited fullerene C60-containing composites decrease viability of transformed cells, intensify the process of lipid peroxidation (LPO) in cell membranes and accumulation of low-molecular weight DNA fragments, and also decrease the activity of electron-transport chain of mitochondria.

Keywords

C60 fullerene composites normal and transformed cells photoexcitation reactive oxygen species 

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Copyright information

© Springer Science + Business Media B.V 2008

Authors and Affiliations

  • S. V. Prylutska
    • 1
  • I. I. Grynyuk
    • 1
  • O. P. Matyshevska
    • 1
  • A. A. Golub
    • 2
  • A. P. Burlaka
    • 4
  • Yu. I. Prylutskyy
    • 3
  • U. Ritter
    • 5
  • P. Scharff
    • 5
  1. 1.Departments of BiochemistryKyiv National Shevchenko UniversityKyivUkraine
  2. 2.Departments of ChemistryKyiv National Shevchenko UniversityKyivUkraine
  3. 3.Departments of BiophysicsKyiv National Shevchenko UniversityKyivUkraine
  4. 4.R.E. Kavetsky Institute of Experimental Pathology, Oncology, and RadiobiologyKyivUkraine
  5. 5.Institute of PhysicsTechnical University of IlmenauIlmenauGermany

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