Abstract
The design and preparation of complex bio-functional glyconanoparticles (GNPs) and their application as polyvalent tools to study and intervene in carbohydrate mediated biological interactions are highlighted. As examples, the preparation and study of GNPs as anti-adhesion agents in inhibition of metastasis, as potential microbicides for blocking HIV-1 infection, or as anti-cancer vaccines are also discussed. In addition, magnetic glyconanoparticles for application in cellular labelling and magnetic resonance imaging (MRI) are also reviewed.
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References
US NIH Nanomedicine road map.
European Science Foundation (ESF) nanomedicina report www.esf.org/publication/214/Nanomedicine.pdf
E. Katz and I. Willner, Integrated nanoparticle-biomolecule hybrid systems: Synthesis, properties, and applications, Angew. Chem. Int. Ed. 33, 6042–6108 (2004).
J. M. de la Fuente and S. Penadés, Understanding carbohydrate-carbohydrate interactions by means of glyconanotechnology, Glycoconj. J. 21(3/4), 149–163 (2004).
J. M. Perez, L. Josephson, and R. Weissleder, Use of magnetic nanoparticles as nanosensors to probe for molecular interactions, ChemBioChem 5(3), 261–264 (2004).
J. M. Polak and I. M. Varndell, Immunolabeling for electron microscopy (Elsevier Science Publishers, Amsterdam, 1984).
C. M. Niemeyer, Nanoparticles, proteins, and nucleic acids: biotechnology meets materials science, Angew. Chem. Int. Ed. 40(22), 4128–4158 (2001).
C. B. Murray, C. R. Kagan, and M. G. Bawendi, Synthesis and characterization of monodisperse nanocrystals and close-packed nanocrystal assemblies, Annu. Rev. Mater. Sci. 30, 545–610 (2000).
M.-C. Daniel and D. Astruc, Gold nanoparticles: Assembly, supramolecular chemistry, quantum-size-related properties, and applications towards biology, catalysis and nanotechnology, Chem. Rev. 104(1), 293–346 (2004).
U. Drechsler, B. Erdogan, and V. M. Rotello, Nanoparticles: Scaffolds for molecular recognition, Chem.-Eur. J. 10(22), 5570–5579 (2004).
A. Verma and V. M. Rotello, Surface recognition of biomacromolecules using nanoparticle receptors, Chem. Comm. 3, 303–312 (2005).
J. Wang, Nanomaterial-based amplified transduction of biomolecular interactions, Small 1(11), 1036–1043 (2005).
D. L. Huber, Synthesis, properties, and applications of iron nanoparticles, Small 1(5), 482–501 (2005).
J. M. de la Fuente, A. G. Barrientos, T. C. Rojas, J. Rojo, J. Cañada, A. Fernández, and S. Penadés, Gold glyconanoparticles as water-soluble polyvalent models to study carbohydrate interactions, Angew. Chem. Int. Ed. 40(12), 2257–2261 (2001).
A. Frey, K. T. Giannasca, R. Weltzin, P. J. Giannasca, H. Reggio, W. I. Lencer, and M. R. Neutra, Role of glycocalyx in regulating access of microparticles to apical plasma membranes of intestine epithelial cells: Implications for microbial attachment and oral vaccine targeting, J. Exp. Med. 184(3), 1045–1059 (1996).
A. Varki, Biological roles of oligosaccharides: All of the theories are correct, Glycobiology 3(2), 97–130 (1993).
R. A. Dwek, Glycobiology: Toward understanding the function of sugars, Chem. Rev. 96(2), 683–720 (1996).
A. G. Barrientos, J. M de la Fuente, T. C. Rojas, A. Fernández, and S. Penadés, Gold glyconanoparticles: synthetic polyvalent ligands mimicking glycocalyx-like surfaces as tools for glycobiological studies, Chem.-Eur. J. 9(9), 1909–1921 (2003).
J. M. de la Fuente and S. Penadés, Glyco-quantum dots: a new luminescent system with multivalent carbohydrate display, Tetrahedron: Asymmetry 16(2), 387–391 (2005).
T. C. Rojas, J. M. de la Fuente, A. G. Barrientos, S. Penadés, L. Ponsonnet, and A. Fernandez, Gold glyconanoparticles as building blocks for nanomaterials design, Adv. Mater. 14(8), 585–588 (2002).
M. Brust, J. Fink, D. Bethell, D. J. Schiffrin, and C. J. Kiely, Synthesis and reactions of functionalised gold nanoparticles, J. Chem. Soc. Chem. Commun. (1995) 1655–1656.
M. J. Hernáiz, J. M. de la Fuente, A. G. Barrientos, and S. Penadés, A model system mimicking glycosphingolipid clusters to quantify carbohydrate self-interactions by surface plasmon resonance, Angew. Chem. Int. Ed. 41(9), 1554–1557 (2002).
J. M. de la Fuente, P. Eaton, A.G. Barrientos, M. Menedez, and S. Penadés, Thermodynamic evidence for Ca2 + -mediated self-aggregation of Lewis X gold glyconanoparticles. A model for cell adhesion via carbohydrate-carbohydrate interaction, J. Am. Chem. Soc. 127(17), 6192–6197 (2005).
J. Rojo, V. Diaz, J. M. de la Fuente, I. Segura, A. G. Barrientos, H. H. Riese, A. Bernad, and S. Penadés, Gold glyconanoparticles as new tools in antiadhesive therapy, ChemBioChem 5(3), 291–297 (2004).
R. Ojeda, J. L. de Paz, A. G. Barrientos, M. Martín-Lomas, and S. Penadés, Preparation of multifunctional glyconanoparticles as a platform for potential carbohydrate-based anticancer vaccines, Carbohyd. Res. 342, 448–459 (2007).
For a recent review see: J. M. de la Fuente and S. Penadés, Glyconanoparticles: types, synthesis and application in glycoscience, biomedicine and material science, Biochim. Biophys. Acta, 1760(4), 636–651 (2006).
S. Hakomori, Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens, Adv. Cancer Res. 52, 257–331 (1989).
European Microbicides Project (EMPRO); http://www.empro.org.uk/home.php4.
T. B. H. Geijtenbeek, D. S. Kwon, R. Torensma, S. J. van Vliet, G. C. F. van Duijnhoven, J. Middel, I. L. Cornelissen, H. S. Nottet, V. N. Kewal-Ramani, D. R. Littman, C. G. Figdor, and Y. van Kooyk, DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells, Cell 100, 587–597 (2000).
Y. Guo, H. Feinberg, E. Conroy, D. A. Mitchell, R. Alvarez, O. Blixt, M. E. Taylor, W. I. Weis, and K. Drickamer, Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR, Nat. Struct. Mol. Biol. 11(7), 591–598 (2004).
C. C. Berry and A. S. G. Curtis, Functionalisation of magnetic nanoparticles for applications in biomedicine, J. Phys. D: Appl. Phys. 36, R198–206 (2003).
Q. A. Pankhurst, J. Connolly, S. K. Jones, and J. Dobson, Applications of magnetic nanoparticles in biomedicine, J. Phys. D: Appl. Phys. 36, R167–181 (2003).
P. Tartaj, M. P. Morales, S. Veintemillas-Verdaguer, T. Gonzalez-Carreño, and C. J. Serna, The preparation of magnetic nanoparticles for applications in biomedicine, J. Phys, D: Appl. Phys. 36, R182–R197 (2003).
J. M. de la Fuente, D. Alcántara, P. Eaton, P. Crespo, T. C. Rojas, A. Fernández, A. Hernando, and S. Penadés, Gold and gold-iron oxide magnetic glyconanoparticles: Synthesis, characterization and magnetic properties, J. Phys. Chem. B, 110(26), 13021–13028 (2006).
P. Crespo, M. A. García, E. Fernández, M. Multigner, D. Alcántara, J. M. de la Fuente, S. Penadés, and A. Hernando, Fe impurities weaken the ferromagnetic behavior in Au glyconanoparticles, Phys. Rev. Lett. 97, 177203 (2006).
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Penadés, S., de la Fuente, J.M., Barrientos, Á.G., Clavel, C., Martínez-Ávila, O., Alcántara, D. (2008). Multifunctional Glyconanoparticles : Applications in Biology and Biomedicine. In: Giersig, M., Khomutov, G.B. (eds) Nanomaterials for Application in Medicine and Biology. NATO Science for Peace and Security Series. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6829-4_8
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DOI: https://doi.org/10.1007/978-1-4020-6829-4_8
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