Isohelical DNA-Binding Oligomers: Antiviral Activity and Application for the Design of Nanostructured Devices

  • Georgy Gursky
  • Alexei Nikitin
  • Anna Surovaya
  • Sergey Grokhovsky
  • Valeria Andronova
  • Georgy Galegov
Conference paper
Part of the NATO Science for Peace and Security Series book series (NAPSB)

Abstract

We performed a systematic search for new structural motifs isohelical to double-stranded DNA and found five motifs that can be used for the design and synthesis of new DNA-binding oligomers. Some of the DNA-binding oligomers can be equipped with fluorescence chromophores and metal-chelating groups and may serve as conductive wires in nano-scaled electric circuits. A series of new DNA-binding ligands were synthesized by a modular assembly of pyrrole carboxamides and novel pseudopeptides of the form (XY)n. Here, Y is a glycine residue; n is the degree of polymerization. X is an unusual amino acid residue containing a five-membered aromatic ring. Antiviral activity of bis-linked netropsin derivatives is studied. Bis-netropsins containing 15 and 31 lysine residues at the N-termini inhibit most effectively reproduction of the herpes virus type 1 in the Vero cell culture, including virus variants resistant to acyclovir and its analogues. Antiviral activity of bis-linked netropsin derivatives is correlated with their ability to interact with long clusters of AT-base pairs in the origin of replication of the viral DNA.

Keywords

Isohelical DNA-binding oligomers conductive polymers nano-structured devices DNA sequence recognition antiviral activity 

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Copyright information

© Springer Science + Business Media B.V 2008

Authors and Affiliations

  • Georgy Gursky
    • 1
  • Alexei Nikitin
    • 1
  • Anna Surovaya
    • 1
  • Sergey Grokhovsky
    • 1
  • Valeria Andronova
    • 2
  • Georgy Galegov
    • 2
  1. 1.V.A. Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscowRussia
  2. 2.D.I. Ivanovsky Institute of VirologyRussian Academy of Medical SciencesMoscowRussia

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