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Innate and Adaptive Immunity in the Tumor Microenvironment pp 171–193Cite as

Natural Killer Cells at the Tumors Microenvironment

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Part of the book series: The Tumor Microenvironment ((TTME,volume 1))

NK cells have the innate ability to recognize and eliminate transformed cells. However, tumors still form and progress in seemingly immune-competent individuals. The tumor microenvironment controls NK recruitment and maintenance in situ. Current understanding of NK basic biology explain in part their limitations, that might turn the anti-cancerous devotion into a tumor progression outcome. Recent progress in understanding of the evasion from NK recognition and counterattack against the killer cells are discussed, along with unresolved questions.

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Authors
  1. Roi Gazit
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  2. Ofer Mandelboim
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  1. Lautenberg Center for General and Tumor Immunology, Hebrew University—Hadassah Medical School, Jerusalem, Israel

    Eitan Yefenof

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Gazit, R., Mandelboim, O. (2008). Natural Killer Cells at the Tumors Microenvironment. In: Yefenof, E. (eds) Innate and Adaptive Immunity in the Tumor Microenvironment. The Tumor Microenvironment, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6750-1_9

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