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Local Tumor Growth and Spontaneous Systemic T Cell Responses in Cancer Patients: A Paradox and Puzzle

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Innate and Adaptive Immunity in the Tumor Microenvironment

Part of the book series: The Tumor Microenvironment ((TTME,volume 1))

We describe and discuss the paradox situation that in many cancer patients functional antitumor memory T cells can be detected in their bone marrow which coexist with a growing tumor in the periphery. This phenomenon, known as “concomitant immunity” suggests that the tumor and its microenvironment prevent systemic antitumor immunity to become effective. Strategies of intervention at the tumor microenvironment are being discussed.

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Authors and Affiliations

  1. Division of Cellular Immunology, German Cancer Research Center, Heidelberg, Germany

    Philipp Beckhove & Volker Schirrmacher

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  1. Philipp Beckhove
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  2. Volker Schirrmacher
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  1. Lautenberg Center for General and Tumor Immunology, Hebrew University—Hadassah Medical School, Jerusalem, Israel

    Eitan Yefenof

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Beckhove, P., Schirrmacher, V. (2008). Local Tumor Growth and Spontaneous Systemic T Cell Responses in Cancer Patients: A Paradox and Puzzle. In: Yefenof, E. (eds) Innate and Adaptive Immunity in the Tumor Microenvironment. The Tumor Microenvironment, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6750-1_3

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