This study addresses the impact of family history of disease and family history of longevity on cause-specific mortality in a large population-based cohort. We identified a cohort of 464,494 people born between 1830 and 1984 from the Utah Population Database, a resource of linked genealogy, vital statistics, and disease data. To be eligible, a cohort member must have lived at least 65 years and died between 1904 and 2002. We measured familial disease risks using the familial standardized mortality ratio (FSMR), and familial longevity using familial excess longevity (FEL). For each of the leading causes of death in the U.S., we constructed a nested casecontrol study using cohort members dying of a specific cause (cases) and individually matched cohort members who remained at risk at the time of the cases’ deaths (controls). Our results indicate that family histories of cause-specific mortality greatly affect risk of death from the same cause, especially for heart disease, cancer, and diabetes. However, familial excess longevity is associated with decreased risks of almost all causes of death, suggesting that whatever factors link kin survival, an important component is the familiality of longevity within their extended family. The one major disease for which familial longevity confers no substantial protection is cancer, suggesting that there may be some antagonism between genetic mechanisms that protect against aging and those that protect against cancer.
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References
Allen, R.D. 1989. Religion in twentieth-century Utah, in R.D. Poll, T.G. Alexander, E.E. Campbell, and D.E. Miller (eds.), Utah’s history, Utah State University Press, Logan, pp. 609–27.
Anderson, R.N. and B.L. Smith. 2005. Deaths: Leading causes for 2002. National Vital Statistics Reports 53(17): 1–89.
Anderton, D.L. and L.L. Bean. 1985. Birth spacing and fertility limitation: A behavioral analysis of a nineteenth century frontier population. Demography 22: 169–83.
Anderton, D.L. and S.H. Leonard. 2004. Grammars of death: An analysis of nineteenth-century literal causes of death from age of miasmas to germ theory. Social Science History 28(1): 111–43.
Bardet, J.P., K.A. Lynch, G.P. Mineau, M. Hainsworth, and M. Skolnick. 1981. La mortalité maternelle autrefois: Une étude comparée. Annales de Démographie Historique: 31–49.
Bean, L.L., G.P. Mineau, and D.L. Anderton. 1990. Fertility Change on the American Frontier, Adaptation and Innovation. University of California Press, Berkeley.
Beeton, M. and K. Pearson. 1899. Data for the problem of evolution in man. II. A first study on the inheritance of longevity and the selective death rate in man. Proceedings of the Royal Society London 65: 290–305.
Bocquet-Appel, J.P. 1990. Familial transmission of longevity. Annals of Human Biology 17(2): 81–95.
Bruzzi, P., S.B. Green, D.P. Byar, L.A. Brinton, and C. Schairer. 1985. Estimating the population attributable risk for multiple risk factors using case-control data. American Journal of Epidemiology 122: 904–14.
Cannon-Albright, L.A., N. Camp, J.M. Farnham, J. MacDonald, K. Atbin, and K. Rowe. 2003. A genealogical assessment of heritable predisposition to aneurysms. Journal of Neurosurgery 99: 637–43.
Carey, J.R. 2003. Longevity: The Biology and Demography of Life Span. Princeton University Press, Princeton, NJ.
Carey, J.R. and S. Tuljapurkar (eds.). 2003. Life Span: Evolutionary, Ecological, and Demographic Perspectives. Population Council, New York.
Gavrilov, L.A., N.S. Gavrilova, S.J. Olshansky, and B.A. Carnes. 2002. Genealogical data and the biodemography of human longevity. Social Biology 49(3–4): 160–73.
Gudmundsson, H., D.F. Gudbjartsson, M. Frigge, J.R. Gulcher, and K. Stefansson. 2000. Inheritance of human longevity in Iceland. European Journal of Human Genetics 8(10): 743–9.
Hunt, S.C., K. Blickenstaff, P.N. Hopkins, and R.R. Williams. Coronary disease and risk factors in close relatives of Utah women with early coronary death. The Western Journal of Medicine 145(3): 329–34.
Jorde, L.B. 1989. Inbreeding in the Utah Mormons: An evaluation of estimates based on pedigrees, isonymy, and migration matrices. Annals of Human Genetics 52: 339–55.
Jorde, L.B. 2001. Consanguinity and prereproductive mortality in the Utah Mormon population. Human Heredity 52: 61–5.
Kerber, R.A. 1995. Method for calculating the risk associated with family history of a disease. Genetic Epidemiology 12(3): 291–301.
Kerber, R.A., E. O’Brien, K.R. Smith, and R.M. Cawthon. 2001. Familial excess longevity in Utah genealogies. The Journal of Gerontology: Biological Sciences 56A(3): B130–9.
Kerber, R.A. and E. O’Brien. 2005. A cohort study of cancer risk in relation to family histories of cancer in the Utah population database. Cancer 103(9): 1906–15.
Langholz, B. and D.C. Thomas. 1991. Efficiency of cohort sampling designs: Some surprising results. Biometrics 47(4): 1563–71.
Liddell, F.D.K., J.C. McDonald, and D.C. Thomas. 1977. Methods of cohort analysis: Appraisal by application to asbestos mining. Journal of the Royal Statistical Society Series A 140: 469–91.
Lynch, K.A., G.P. Mineau, and D.L. Anderton. 1985. Estimates of infant mortality on the Western frontier: The use of genealogical data. Historical Methods 18: 155–64.
Malecot, G. 1948. The Mathematics of Heredity. Masson, Paris.
Mineau, G.P. 1988. Utah widowhood: a demographic profile, in A. Scadron (ed.), On their own: Widows and widowhood in the American Southwest, 1848–1939, University of Illinois Press, Champaign, pp. 140–65.
Mineau, G.P., K.R. Smith, and L.L. Bean. 2002. Historical trends of survival among widows and widowers. Social Sciences and Medicine 54: 245–54.
Mineau, G.P., K.R. Smith, and L.L. Bean. 2004. Adult mortality risks and religious affiliation: The role of social milieu in biodemographic studies. Annales de Démographie Historique: 85–104.
O’Brien, E., R.A. Kerber, L.B. Jorde, and A.R. Rogers. 1994. Founder effect assessment of variation in genetic contributions among founders. Human Biology 66: 185–204.
Smith, K.R. and G.P. Mineau. 2003. Genealogies in demographic research, in P. Demeny and G. McNicholl (eds.), Encyclopedia of population, Macmillan, New York, pp. 448–51.
Smith, K.R., G.P. Mineau, and L.L. Bean. 2002. Fertility and post-reproductive longevity. Social Biology 49(1): 55–75.
Wachter, K.W. and C.E. Finch (eds.) 1997. Between Zeus and the Salmon: The Biodemography of Longevity. National Academy Press, Washington, DC.
Wahlquist, W.L. 1974. Settlement processes in the Mormon core area: 1847–1890. Ph.D. Dissertation, University of Nebraska.
Williams, R.R. 1980. A population perspective for early and familial coronary heart disease, in J. Cairns, J.L. Lyon, and M. Skolnick (eds.), Banbury report no. 4: Cancer incidence in defined populations, Cold Spring Harbor Laboratory Press, Cold Spring, New York, pp. 333–50.
Williams, R.R., M. Skolnick, D. Carmelli, A.T. Maness, S.C. Hunt, S. Hasstedt, G.E. Reiber, and R.K. Jones. 1978. Utah pedigree studies: Design and preliminary data for premature male CHD deaths. Paper read at Genetic analysis of common diseases: Applications to predictive factors in coronary disease, Snowbird, Utah.
Wylie, J.E. and G.P. Mineau. 2003. Biomedical databases: Protecting privacy and promoting research. Trends in Biotechnology 21: 113–6.
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Kerber, R., O'Brien, E., Smith, K.R., Mineau, G.P. (2008). Familial Aggregation of Elderly Cause-Specific Mortality: Analysis of Extended Pedigrees in Utah, 1904–2002. In: Bengtsson, T., Mineau, G.P. (eds) Kinship and Demographic Behavior in the Past. International Studies in Population, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6733-4_11
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