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Macrophages in tumour development and metastasis

  • Chapter
Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response

Part of the book series: Cancer Growth and Progression ((CAGP,volume 11))

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Abstract

Activated stromal cells, e.g. inflammatory cells, fibroblasts and vascular cells, present in tumour microenvironments profoundly influence neoplastic development and progression to the tumour state. Macrophages are multifunctional immune cells that often constitute a major component of the inflammatory cell repertoire associated with premalignant and malignant tissues. Macrophages are recruited from the blood circulation by tumour-derived chemoattractants and preferentially localize to hypoxic tumour regions. Depending on their activation status and microenvironment, macrophages can impact tumour development and progression by either positive or negative mechanisms. Based upon this duality, the macrophage balance theory was proposed to emphasize complex relationships between tumourassociated macrophages and neoplastic cells. When appropriately activated, as during acute inflammatory responses, macrophages manifest an M1 phenotype and gain tumouricidal capacities; however, under adverse conditions present within tumour microenvironments, macrophages adopt an M2 phenotype and functionally contribute to neoplastic progression and overall tumour development.

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Authors and Affiliations

  1. Department of Pathology, University of California, San Francisco, 2340 Sutter Street, N-221, San Francisco, CA, 94143

    Alexandra Eichten & Lisa M. Coussens

  2. Department of Molecular Biology, University of California, San Francisco, 2340 Sutter Street, N-221, San Francisco, CA, 94143

    Karin E. de Visser

  3. Cancer Research Institute, University of California, San Francisco, 2340 Sutter Street, N-221, San Francisco, CA, 94143

    Lisa M. Coussens

  4. Comprehensive Cancer Center, University of California, San Francisco, 2340 Sutter Street, N-221, San Francisco, CA, 94143

    Lisa M. Coussens

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  1. Department of Pathology, School of Medicine, University of Maryland, Baltimore, MD, USA

    Hans E. Kaiser

  2. Department of Clinical Pathology, University of Vienna, Austria

    Hans E. Kaiser

  3. Department of Interdisciplinary Oncology-Pathology, Moffit Cancer Center & Research Institute, Tampa, FL, USA

    Aejaz Nasir

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Eichten, A., de Visser, K.E., Coussens, L.M. (2008). Macrophages in tumour development and metastasis. In: Kaiser, H.E., Nasir, A. (eds) Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response. Cancer Growth and Progression, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6729-7_8

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