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Tumor angiogenesis, antiangiogenic therapy and anti-antiangiogenesis response

  • Chapter
Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response

Part of the book series: Cancer Growth and Progression ((CAGP,volume 11))

Abstract

Tumor growth and metastasis require new blood vessel formation, i.e. angiogenesis. Antiangiogenic therapy is emerging as a novel and potentially promising anti-cancer approach. A variety of strategies targeting tumor angiogenesis have been developed and tested in preclinical and clinical settings. The overall efficacy of antiangiogenic therapy, however, is yet to be improved. In this regard, how tumors respond to antiangiogenic therapy needs to be further investigated. Recent research suggests that tumor cells could counteract the effects of anti-endothelial inhibitors, i.e. they are not only angiogenic but also anti-antiangiogenic. The anti-antiangiogenic phenotype of tumor cells might be genetically driven. Specifically, oncogenic alterations acquired in tumor cells could provide surviving signals to endothelial cells and confer a resistance to endothelial targeting therapies. When using an anti-endothelial treatment, simultaneously suppressing the anti-antiangiogenic property of tumor cells might be essential. Based on this consideration, combination of direct and indirect antiangiogenic therapies might represent a useful strategy to achieve effective inhibition of tumor angiogenesis.

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Authors and Affiliations

  1. University of Pittsburgh Cancer Institute, Pittsburgh, PA, 15213, USA

    Mengfeng Li

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  1. Mengfeng Li
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Editors and Affiliations

  1. Department of Pathology, School of Medicine, University of Maryland, Baltimore, MD, USA

    Hans E. Kaiser

  2. Department of Clinical Pathology, University of Vienna, Austria

    Hans E. Kaiser

  3. Department of Interdisciplinary Oncology-Pathology, Moffit Cancer Center & Research Institute, Tampa, FL, USA

    Aejaz Nasir

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Li, M. (2008). Tumor angiogenesis, antiangiogenic therapy and anti-antiangiogenesis response. In: Kaiser, H.E., Nasir, A. (eds) Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response. Cancer Growth and Progression, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6729-7_6

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