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A biodynamical model of human T-cell development and pathology: design, testing and validation

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Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response

Part of the book series: Cancer Growth and Progression ((CAGP,volume 11))

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Abstract

We describe a coupled ordinary differential equation model of human T-cell proliferative disorders based upon documented changes in various pools such as the bone marrow, thymic compartments and peripheral blood. The conceptual design of the model is based upon previously collected experimental data, its testing and validation by comparing with normal human cell pool data at various ages as well as their changes in response to HTLV-1, HHV-6 and HIV-1 viral infections. These viruses were chosen because they all target the same CD4 lymphocyte, yet produce different response patterns such as hyperplasia, aplasia and neoplasia. They were also selected because respective cell pool data were available for comparison with detailed human studies. The ultimate task of this modeling effort is to simulate the development of T-cell lymphomas and other immunoproliferative or aproliferative (i.e. aplastic) abnormalities reported in the literature.

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Authors and Affiliations

  1. University of Texas-Houston Health Science Center – Medical School, USA

    Michael E. Brandt, Gerhard R. F. Krueger & Guanyu Wang

  2. School of Health Information Sciences, USA

    Michael E. Brandt

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  1. Michael E. Brandt
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  2. Gerhard R. F. Krueger
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  3. Guanyu Wang
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Editors and Affiliations

  1. Department of Pathology, School of Medicine, University of Maryland, Baltimore, MD, USA

    Hans E. Kaiser

  2. Department of Clinical Pathology, University of Vienna, Austria

    Hans E. Kaiser

  3. Department of Interdisciplinary Oncology-Pathology, Moffit Cancer Center & Research Institute, Tampa, FL, USA

    Aejaz Nasir

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Brandt, M.E., Krueger, G.R.F., Wang, G. (2008). A biodynamical model of human T-cell development and pathology: design, testing and validation. In: Kaiser, H.E., Nasir, A. (eds) Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response. Cancer Growth and Progression, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6729-7_13

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