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Characterization of tumor-directed cellular immune responses in humans

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Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response

Part of the book series: Cancer Growth and Progression ((CAGP,volume 11))

Abstract

Understanding tumor/host immune interactions may help to fight cancer. Growing knowledge about T cell responses and increasing success of immunotherapeutic approaches have created the need for methods to characterize tumor-directed cellular immune responses. The spectrum of methods reaches from protein-based methods, including tetramers or intracellular flow cytometry, to genetic assays, such as TCR analysis or microarray techniques, further on to functional assays analysing proliferation and microtoxicity. Here, we describe these and further methods and explain their respective application in human tumor immunology.

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Authors and Affiliations

  1. Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD

    Dirk Nagorsen MD, Vladia Monsurro PhD & Francesco M. Marincola MD

  2. Department of Transfusion Medicine, Clinical Center, NIH, Building 10, Room 1C711, 10 Center Drive, Bethesda, MD, 20892-1502, USA

    Francesco M. Marincola MD

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  1. Dirk Nagorsen MD
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  2. Vladia Monsurro PhD
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  3. Francesco M. Marincola MD
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Editors and Affiliations

  1. Department of Pathology, School of Medicine, University of Maryland, Baltimore, MD, USA

    Hans E. Kaiser

  2. Department of Clinical Pathology, University of Vienna, Austria

    Hans E. Kaiser

  3. Department of Interdisciplinary Oncology-Pathology, Moffit Cancer Center & Research Institute, Tampa, FL, USA

    Aejaz Nasir

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Nagorsen, D., Monsurro, V., Marincola, F.M. (2008). Characterization of tumor-directed cellular immune responses in humans. In: Kaiser, H.E., Nasir, A. (eds) Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response. Cancer Growth and Progression, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6729-7_10

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