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Coenzyme Q10 Supplementation in Experimental Medicine

  • Anna Gvozdjáková
  • Jaromír Horecký
  • Ol'ga Vančová
  • Jarmila Kucharská
  • Katarína Bauerová
  • Silvester Poništ

Original minimally invasive surgical procedure for three-vascular occlusion (3-VO) model of Alzheimer’s vascular dementia (AD) in aged rats was developed. The main pathological changes observed following 50-min brain ischemia were characterized by decreased parameters of oxidative phosphorylation in brain and heart mitochondria. Four weeks supplementation of liposoluble CoQ10 after cerebral ischemia/reperfusion (I/R) injury, regenerated AD brain and myocardium mitochondrial oxidative phosphorylation function. These results indicate, that CoQ10 supplementation may stimulate regeneration of the damaged brain and heart mitochondria in patients with Alzheimer’s disease.

Keywords

Alzheimer’s disease model of 3-VO brain and heart mitochondria brain I/R injury Coenzyme Q10 

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© Springer Science + Business Media B.V 2008

Authors and Affiliations

  • Anna Gvozdjáková
    • Jaromír Horecký
      • 1
    • Ol'ga Vančová
      • Jarmila Kucharská
        • Katarína Bauerová
          • 2
        • Silvester Poništ
          • 2
        1. 1.Surgical Pathophysiology and Tissue Engeneering CenterSlovak Medical UniversitySlovakia
        2. 2.Slovak Academy of SciencesInstitute of Experimental PharmacologySlovakia

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