Abstract
The progress of the biomedical sciences poses new philosophical, moral and legal questions. A transdisciplinary approach is ideal for addressing such questions and achieving a mutual understanding of the underlying biological facts. In this debate it becomes obvious that biomedical research per se does not provide a useful terminology for legislation. A transdisciplinary approach is therefore essential to achieve a common, accepted terminology and reach an agreement on the pertinent problems; both prerequisites for timely legislation.
The artificial creation of human–animal mixtures for research and therapeutic purposes touches very sensitive moral and legal issues. The novel procedures raise the question of the relevance of natural boundaries between species. The extent to which the species barrier has and will be breached by such experimental procedures which use biological entities at various developmental stages, in particular in the context of the use of human embryonic stem cells, is a strong challenge for scientists, ethicists, legislators and society. In view of pending and forthcoming legislation, it is the intention of this transdisciplinary approach to review and analyse the respective biomedical research agendas which have to be taken into account in the normative discussion.[-12pt]
First, we present the current relevant constitutional and statute laws ofbreak Switzerland. We then review recent developments in biological research involving human–animal mixtures, including chimeras, which are likely to become issues for regulatory action. The compilation covers a broad range of human–animal mixtures, with a focus on the use of human embryonic stem cells for basic research and therapeutic procedures. We finally address some other recent biomedical developments that could have an impact on terminology and legal definitions used in the current Swiss regulations.
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References
Almeida-Porada, G., Porada, C., and Zanjani, E.D.: 2004, Plasticity of human stem cells in the fetal sheep model of human stem cell transplantation, Int J Hematol 79, 1–6.
Bernhard, H.P., Rubin-Lucht, B., and Schweizer, R.J.: 2006, Chimeras and Hybrids in Comparative European and International Research, CHIMBRIDS Opening Conference, Mannheim.
Borlongan, C.V. and Sanberg, P.R.: 2002, Neural transplantation for treatment of Parkinson’s disease, Drug Discov Today 7, 674–82.
Chen, Y., He, Z.X., Liu, A., Wang, K., Mao, W.W., Chu, J.X., Lu, Y., Fang, Z.F., Shi, Y.T., Yang, Q.Z., Chen, D.Y., Wang, M.K., Li, J.S., Huang, S.L., Kong, X.Y., Shi, Y.Z., Wang, Z.Q., Xia, J.H., Long, Z.G., Xue, Z.G., Ding, W.X., and Sheng, H.Z.: 2003, Embryonic stem cells generated by nuclear transfer of human somatic nuclei into rabbit oocytes, Cell Res 13, 251–263.
Federal Constitution of the Swiss Confederation of April 18, 1999, Retrieved June 5, 2007, from http://www.admin.ch/ch/itl/rs/1/c101ENG.pdf.
Flax, J.D., Aurora, S., Yang, C., Simonin, C., Wills, A.M., Billinghurst, L.L., Jendoubi, M., Sidman, R.L., Wolfe, J.H., Kim, S.U., and Snyder, E.Y. : 1998, Engraftable human neural stem cells respond to development cues, replace neurons and express foreign genes, Biotechnology 16, 1033–1039.
Hubner, K., Fuhrmann, G., Christenson, L.K., Kehler, J., Reinbold, R., De La Fuente, R., Wood, J., Strauss, J.F., Boiani, M., and Scholer, H.R : 2003, Derivation of oocytes from mouse embryonic stem cells, Science 300, 1251–1256.
Mc Cune, J.M., Namikawa, R., Kaneshima, H., Shulz, L.D., Liebermann, M., and Weissmann, I.L.: 1988, The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function, Science 241, 1632–1639.
Meissner, A. and Jaenisch, R.: 2006, Generation of nuclear transfer-derived pluripotent mouse embryonic stem cells from cloned Cdx2-deficient blastocysts, Nature 439, doi.10.1038, 1–4.
Muotri, A.R., Nakashima, K., Toni, N., Sandler, V.M., and Gage, F.H.: 2005, Development of functional human embryonic stem cell-derived neurons in mouse brain, Proc Natl Acad Sci USA 102, 18644–18648.
Ogle, B.M., Butters, K.A., Plummer, T.B., Ring, K.R., Knudsen, B.E., Litzow, M.R., Cascalho, M., and Platt, J.L.: 2004, Spontaneous fusion of cells between species yields transdifferentiation and retroviral transfer in vivo, Faseb J 18, 548–550.
O’Brian, M.L., Pendola, J.K., and Eppig, J.K.: 2003, A revised protocol for in vitro development of mouse oocytes from primordial follicles dramatically improves their developmental competence, Biol Reprod 68, 682–1686.
O’Doherty, A., Ruf, S., Mulligan, C., Hildreth, V., Errington, M.L., Cooke, S., Sesay, A., Modino, S., Vanes, L., Hernandet, D., Linehan, M., Sharpe, P.T., Brandner, S., Bliss, T.V.P., Henderson, D.J., Nizetic, D., Tybulewicz, L.J., and Fisher, E.M.C.: 2005, An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes, Science 309, 2033–2037.
Reusser, R. and Schweizer, R.J.: 2002. In: B. Ehrenzeller, Ph. Mastronardi, R.J. Schweizer, and K. Vallender (eds), Commentary to the Swiss Federal Constitution, Zürich, Commentary to Art. 119, 1211–1229.
Toyooka, Y., Tsunekawa, N., Akasu, R., and Noce, T.: 2003, Embryonic stem cells can form germ cells in vitro, Proc Natl Acad Sci USA 100, 11457–11462.
Vanderbyl, G.N., Mac Donald, G.M., Sidhu, S., Gung, L., Telenius, A., Perez, C., and Perkins, E.: 2004, Transfer and stable transgene expression of mammalian artificial chromosomes into bone marrow-derived human mesenchymal stem cells, Stem Cells 22, 324–333.
Vrana, K.E., Hipp, J.D., Goss, A.M., Mc Cool, B.A., Riddle, D.R., Walker, S.J., Wrrstein, P.J., Studer, L.P., Tabar, V., Cunniff, K., Chapman, K., Vilner, L., West, M.D., Grant, K.A., and Cibelli, J.B.: 2003, Non-human primate parthenogenetic stem cells, Proc Natl Acad Sci USA, 100 Suppl 1, 11911–6.
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Bernhard, H.P., Schweizer, R.J. (2008). Chimeras and Other Human–Animal Mixtures in Relation to the Swiss Constitution: A Case for Regulatory Action. In: Hadorn, G.H., et al. Handbook of Transdisciplinary Research. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6699-3_10
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DOI: https://doi.org/10.1007/978-1-4020-6699-3_10
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