Study Of Metabolism: Cells and Tissues

  • K.V.R. Chary
  • Girjesh Govil
Part of the Focus on Structural Biology book series (FOSB, volume 6)


Body Fluid Cell Free Extract Cerebral Spinal Fluid Magic Angle Spinning Pyruvate Pyruvate 
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6.1 Further Reading

  1. H. Antti, E. Holmes and J. Nicholson, Multivariate Solutions to Metabonomic Profiling and Functional Genomics,∼ tnkjtg/Chemomatrics/Editorial (2002).Google Scholar
  2. D.I. Hoult, S.J. Busby, D.G. Gadian, G.K. Radda, R.E. Richards, and P.J. Seeley, Observation of tissue metabolites using 31 P nuclear magnetic resonance, Nature 252, 285–287 (1974).CrossRefGoogle Scholar
  3. P.A. Srere and J. Ovadi, Enzyme-enzyme interactions and their metabolic role, FEBS Letters 268, 360–364 (1990).CrossRefGoogle Scholar
  4. M. Ala-korpela, A. Korhonen, J. Keisela, S. Horkko, P. Korpi, L.P. Ingman, J. Jokisaari, M.J. Savoloinen and Y.A. Kesalniemi, 1 H NMR-based absolute quantitaion of human lipoproteins and their lipid contents directly from plasma, J. Lipid Res. 35, 2292–2304 (1994).Google Scholar
  5. Z. Argov, M. Lofberg and D.L. Arnold, Insights into muscle diseases gained by phosphorus magnetic resonance spectroscopy, Muscle and Nerve, 23, 1316–1334 (2000).CrossRefGoogle Scholar
  6. D.E. Bugay, Characterization of the solid-state: Spectroscopic techniques, Adv. Drug Deliv. Rev. 48, 43–65 (2001).CrossRefGoogle Scholar
  7. Z. Serber, R. Lewidge, S.M. Miller, and V. Dotsch, Evaluation of parameters critical to observing proteins inside living Escherichia coli by in-cell NMR Spectroscopy, J. Am. Chem. Soc. 123, 8895–8901 (2001).CrossRefGoogle Scholar
  8. J.T. Brindle et al., Rapid and non-invasive diagnosis of the presence and severity of coronary heart disease using 1 H-NMR-based metabonomics, Nat. Med. 8, 1439–1443 (2002).CrossRefGoogle Scholar
  9. J.D. Otvos, E.J. Jeyarajah, and W.C. Cromwell, Measurement Issues related to lipoprotein heterogeneity, Am. J. Cardiol. 90S, 22i–29i (2002).CrossRefGoogle Scholar
  10. O. Corcoran, and M. Spraul, LC-NMR-MS in drug discovery, Drug Discov. Today 8, 624–631 (2003)CrossRefGoogle Scholar
  11. Y.-L. Chung, M. Stubbs, J. Griffiths, Metabolic Profiling in Tumors by in Vivo and in Vitro NMR Spectroscopy in Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis, G.G. Harrigan and R. Goodacre (eds.), (2003).Google Scholar
  12. H. Lei, X.H. Zhu, X.L. Zhang, K. Ugurbil and W. Chen, In vivo 31 P magnetic resonance spectroscopy of human brain at 7 T: An initial experience, Magn. Reson. Med. 49, 199–205 (2003).CrossRefGoogle Scholar
  13. M.R. Viant, E.S. Rosenblum and R.S. Tjeerdema, NMR-based metabonomics: A powerful approach for characterizing the effects of environmental stressors on organism health. Environ. Sci. Technol. 37, 4982–4989 (2003).CrossRefGoogle Scholar
  14. W.H. Dunn, N.J.C. Bailey and H.E. Johnson, Measuring the metabolome: current analytical technologies, Analyst 130, 606–625 (2005).CrossRefGoogle Scholar
  15. M. Mehta, H.M. Sonawat and S. Sharma, Malaria parasite-infected erythrocytes inhibit glucose utilization in uninfected red cells, FEBS Letters 579, 6151–6158 (2005).CrossRefGoogle Scholar
  16. G.A. Nagana Gowda, Omkar B. Ijare, B.S. Somashekar, Ajay Sharma, V.K. Kapoor, and C.L. Khetrapal, Single-step analysis of individual conjugated bile acids in human bile using 1 H NMR Spectroscopy, Lipids 41, 591–613 (2006).CrossRefGoogle Scholar

6.2 Books and Reviews

  1. M.P. Deutscher (ed.), Guide to Protein Purification, Methods Enzymol. 182, 1–894 (1990).Google Scholar
  2. J.M. Berg, J.L. Tymoczko and L. Stryer, Biochemistry, 5th International Edition, W.H. Freeman and Co., (1995).Google Scholar
  3. U. Holzgrabe, NMR Spectroscopy in Drug Development and Analysis, Wiley, (1998).Google Scholar
  4. A.L. Lehninger, Principles of Biochemistry, W.H. Freeman and Co. (2000).Google Scholar
  5. S. Srivastava and G. Govil, Applications of NMR to the study of cells and body fluids, Current Organic Chemistry 5, 1039–1057 (2001).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag London Limited 2008

Authors and Affiliations

  • K.V.R. Chary
    • 1
  • Girjesh Govil
    • 1
  1. 1.Tata Institute of Fundamental ResearchMumbaiIndia

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