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Paraoxonase-1 in Chronic Liver Diseases, Neurological Diseases and HIV Infection

  • Chapter
The Paraoxonases: Their Role in Disease Development and Xenobiotic Metabolism

Part of the book series: Proteins And Cell Regulation ((PROR,volume 6))

Abstract

Over recent years there has been a rapid increase in the number of articles reporting paraoxonase-1 (PON1) alterations in diseases other than arteriosclerosis, and which involve an increased degree of oxidative stress. Chronic liver impairment is associated with decreased serum PON1 activity but with increased serum PON1 concentration; this unusual juxtaposition being explained, perhaps, by the molecular alterations related to collagen synthesis and to the inactivation of the enzyme’s active site by lipid peroxides. Polymorphisms of the PON1 gene have been shown to be associated with an increased development of several neurological diseases and to influence the organism’s capacity to protect against neurotoxins. Many infectious diseases, as HIV infection, produce a high oxidative stress, and alterations in PON1 activity and concentration may be related to the course of the disease

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  1. Centre de Recerca Biomèdica and Department of Internal Medicine, Hospital Universitari de Sant Joan, Reus, Spain

    J. Marsillach, S. Parra, B. Coll, C. Alonso-Villaverde, J. Joven & J. Camps

  2. Department of Clinical Biochemistry and Molecular Genetics, Hospital Clínic Universitari, Barcelona, Spain

    N. Ferré

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  2. S. Parra
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Editors and Affiliations

  1. University of Manchester, U.K

    Bharti Mackness

  2. University of Manchester, U.K

    Mike Mackness

  3. Technion Faculty of Medicine, Haifa, Israel

    Michael Aviram

  4. University of Debrecen, Hungary

    György Paragh

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Marsillach, J. et al. (2008). Paraoxonase-1 in Chronic Liver Diseases, Neurological Diseases and HIV Infection. In: Mackness, B., Mackness, M., Aviram, M., Paragh, G. (eds) The Paraoxonases: Their Role in Disease Development and Xenobiotic Metabolism. Proteins And Cell Regulation, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6561-3_12

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