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Regulation of Intracellular Signal Transduction Pathways by Mechanosensitive Ion Channels

  • Aladin M. Boriek
  • Ashok Kumar
Part of the Mechanosensitivity in Cells and Tissues book series (MECT, volume 1)

Abstract

Only in the past five decades have we begun to understand, on the chemical level, what and how mechanosensitive signaling molecules are involved in the physiological regulation of downstream events in response to mechanical stimulation in health and disease. Currently, the forefront of mechanotransduction is focused on mapping an enormous number of signalling and regulatory signalling pathways that are responsible for sensing and transducing mechanical forces. Mechanosensitive ion channels (MSC) are one of the major classes of molecules involved in mechanosensitive signal transduction. MSC have been described in a wide variety of cell types in many different organisms, ranging from bacteria to mammals. MSC participate in several physiological processes such as touch and pain sensation, salt and fluid balance, blood pressure control, cell volume regulation, and turgor control. Abnormal regulation of the structure and function of MSC may contribute to the pathogenesis of quite a few diseases including neuronal degeneration, muscular dystrophy, cardiac arrhythmias, hypertension, kidney disease, and glioma. Accumulating evidence from our and other groups suggests that MSC may play an important role in the activation of several intracellular mechanosensitive signaling pathways. This review summarizes the recent developments and the state of the current thinking regarding the role of MSC in the regulation of different mechanosensitive signaling proteins and signaling pathways

Keywords

Mechanosensitive ion channels Mechanical stretch Signal transduction Mitogen-activated protein kinase NF-kappa B akt 

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© Springer 2008

Authors and Affiliations

  • Aladin M. Boriek
  • Ashok Kumar

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