Multimodal Activation and Regulation of Neuronal Mechanosensitive Cation Channels
Recent findings show that mechanosensitive cation channels are expressed in the central nervous system. These molecules can be found not only, as expected, in mechanosensory cells but also in neurons not involved in sensory mechanotransduction. The expression of these channels in nonspecialized neurons is related to the need for cells to deal with general functions such as volume and electrolyte homeostasis as well as cell movement regulation. Since adhesion and advance of nerve growth cones are associated with changes in membrane tension and with oscillations of intracellular calcium concentration, mechanosensitive cation channels may play critical roles in neurite growth. In keeping with this, elementary mechanosensitive cation currents can be recorded from membranes of neuronal growth cones.
Large conductance mechanosensitive cation channels have been investigated in central neurons of the leech. A multimodal activation, by membrane potential, intracellular calcium and pH, as well as a powerful modulation by adenosine nucleotides have been recently established. These features are discussed as possible mechanisms enabling these channels to contribute to neurite remodeling.
KeywordsMechanosensitive ion channels Single channel recording TRP channel Adenosine nucleotides
Unable to display preview. Download preview PDF.
- Ambudkar IS (2006) Ca2+ signaling microdomains: platforms for the assembly and regulation of TRPC channels. TrendsPharmacol Sci 27:25–32Google Scholar
- Corey DP, Garcia-Anoveros J, Holt JR, Kwan KY, Lin SY, Vollrath MA, Amalfitano A, Cheung EL, Derfler BH, Duggan A, Geleoc GS, Gray PA, Hoffman MP, Rehm HL, Tamasauskas D, Zhang DS (2004) TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature432:723–730PubMedCrossRefGoogle Scholar
- Erecinska M, Cherian S, Silver IA (2004) Energy metabolism in mammalian brain during development. ProgNeurobiol 73:397–445Google Scholar
- Hamill OP, McBride DW Jr (1996) The pharmacology of mechanogated membrane ion channels. PharmacolRev 48:231–252Google Scholar
- Hurwitz CG, Hu VY, Segal AS (2002) A mechanogated nonselective cation channel in proximal tubule that is ATP sensitive. AmJ Physiol Renal Physiol 283:F93–F104Google Scholar
- Kawakubo T, Naruse K, Matsubara T, Hotta N, Sokabe M (1999) Characterization of a newly found stretch-activated K$Ca,ATP channel in cultured chick ventricular myocytes. AmJ Physiol 276: H1827–H1838Google Scholar
- Kwak J, Wang MH, Hwang SW, Kim T, Lee S, Oh U (2000) Intracellular ATP increases capsaicin-activated channel activity by interacting with nucleotide-binding domains. JNeurosci 20:8298–8304Google Scholar
- Maroto R, Raso A, Wood TG, Kurosky A, Martinac B, Hamill OP (2005) TRPC1 forms the stretch-activated cation channel in vertebrate cells. NatCell Biol 7:179–185Google Scholar
- O’Hagan R, Chalfie M, Goodman MB (2005) The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals. NatNeurosci 8:43–50Google Scholar
- Patel A, Honoré E (2001) Properties and modulation of mammalian 2P domain K+ channels. TrendsNeurosci 24:339–346Google Scholar
- Pellegrino M, Pellegrini M, Simoni A, Gargini C (1990) Stretch-activated cation channels with large unitary conductance in leech central neurons. BrainRes 525:322–326Google Scholar
- Petrov AG, Miller BA, Hristova K, Usherwood PN (1993) Flexoelectric effects in model and native membranes containing ion channels. EurBiophys J 22:289–300Google Scholar
- Sachs F, Morris CE (1998) Mechanosensitive ion channels in nonspecialized cells. RevPhysiol Biochem Pharmacol 132:1–77Google Scholar
- Sackin H (1995) Mechanosensitive channels. AnnuRev Physiol 57:333–353Google Scholar
- Shim S, Goh EL, Ge S, Sailor K, Yuan JP, Roderick HL, Bootman MD, Worley PF, Song H, Ming G (2005) XTRPC1-dependent chemotropic guidance of neuronal growth cones. NatureNeurosci 8:730–735Google Scholar
- Sigurdson WJ, Morris CE (1989) Stretch-activated ion channels in growth cones of snail neurons. JNeurosci 9:2801–2808Google Scholar
- Traut TW (1994) Physiological concentrations of purines and pyrimidines. MolCell Biochem 140: 1–22Google Scholar
- Wan X, Juranka P, Morris CE (1999) Activation of mechanosensitive currents in traumatized membrane. AmJ Physiol 276:C318–C327Google Scholar
- Xu L, Enyeart JJ (2001) Properties of ATP-dependent K+ channels in adrenocortical cells. AmJ Physiol Cell Physiol 280:C199–C215Google Scholar