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Hsp70 in Tumors: Friend or Foe?

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Heat Shock Proteins in Cancer

Part of the book series: Heat Shock Proteins ((HESP,volume 2))

Abstract

Hsp70, the most highly conserved and abundantly induced of the stress proteins, appears to play dual and opposing roles in cancer. On the one hand, Hsp70 promotes growth and survival of tumor cells by engaging misfolded or aggregated proteins and proteins involved in cell proliferation. As such, it endows tumor cells with stress resistance. However, Hsp70 can also promote tumor immunity by stimulating innate immune mechanisms and enhancing cross-presentation of tumor antigens to lymphocytes. In this chapter, we review these opposing functions of HSP70 in the context of potential strategies for its use as a tool in cancer biology and therapy

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Authors and Affiliations

  1. Faculdade de Biociěncias e Instituto de Pesquisas Biomédicas, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil

    Cristina Bonorino & Ana Paula Souza

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  1. Cristina Bonorino
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  2. Ana Paula Souza
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Editors and Affiliations

  1. Harvard Medical School, Boston, U.S.A

    Stuart K. Calderwood

  2. Boston University School of Medicine, Boston, U.S.A

    Michael Y. Sherman

  3. National Research Council CONICET, Mendoza, Argentina

    Daniel R. Ciocca

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Bonorino, C., Souza, A.P. (2007). Hsp70 in Tumors: Friend or Foe?. In: Calderwood, S.K., Sherman, M.Y., Ciocca, D.R. (eds) Heat Shock Proteins in Cancer. Heat Shock Proteins, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6401-2_10

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