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The Immune Self Code: From Correspondence to Complexity

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Part of the book series: Biosemiotics ((BSEM,volume 1))

Codes are conventions of correspondence between realms. These conventions may be considered emergent products of complex microlevel interactions. In this chapter, I illustrate the complexity of coding by discussing the immune self. I argue that our evolving understanding of the immune self bears a striking resemblance to the way our understanding of signs evolved. According to the thesis presented in this chapter, the immune system is a meaning-making system and therefore a biosemiotic analysis of the immune self may shed new light on a variety of unsolved theoretical questions in immunology.

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References

  • Anderson CC, Matzinger P 2000 Danger: the view from the bottom of the cliff. Seminars in Immunology 12:231–238

    Article  CAS  PubMed  Google Scholar 

  • Barbieri M 2003 The Organic Codes. Cambridge University Press, Cambridge

    Google Scholar 

  • Bersini H 2003 Revising idiotypic immune networks. Lecture Notes in Computer Science 2801:164–174

    Article  Google Scholar 

  • Buckland J 2002 Sex is good for you! Nature Reviews Immunology 2:148

    Article  CAS  Google Scholar 

  • Choudhury SRC, Knapp L 2000 Human reproductive failure I: immunological factors. Human Reproduction Update 7:113–134

    Article  Google Scholar 

  • Cohen IR 1994 Kadishman’s tree, Escher’s angels, and the immunological homunculus. In: Coutinho A, Kazatchkine MD (eds) Autoimmunity: Physiology and Disease. Wiley-Liss, New York, pp. 7–18

    Google Scholar 

  • Cohen IR 2000a Discrimination and dialogue in the immune system. Seminar in Immunology 12:21–219

    Google Scholar 

  • Cohen IR 2000b Tending Adam’s Garden. Academic Press, NewYork

    Google Scholar 

  • Efroni S, Cohen I 2002 Simplicity belies a complex system: a response to the minimal model of immunity of Langman and Cohn. Cellular Immunology 216:23–30

    Article  CAS  PubMed  Google Scholar 

  • Efroni S, Cohen IR 2003 The heuristics of biologic theory: the case of self-noself discrimination. Cellular Immunology 223:87–89

    Article  CAS  PubMed  Google Scholar 

  • Howes M 1998 The self of philosophy and the self of immunology. Perspectives in Biology and Medicine 42:118–130

    CAS  PubMed  Google Scholar 

  • Janeway CA Jr. 1992 The immune system evolved to discriminate infectious nonself from noninfectious self. Immunology Today 13:11–16

    Article  CAS  PubMed  Google Scholar 

  • Jerne NK 1974 Toward a network theory of the immune system. Ann. Immunol. (Inst. Pasteur) 125c:373–389

    CAS  Google Scholar 

  • Jerne NK 1984 Idiotypic networks and other preconceived ideas. Immunological Review 79:5–24

    Article  CAS  Google Scholar 

  • Klein J 1982 Immunology: The science of self nonself discrimination. Wiley, London

    Google Scholar 

  • Langman RE, Cohn M 2000 A minimal model for the self-nonself discrimination: a return to the basics. Seminars in Immunology 12:180–195

    Google Scholar 

  • McLachlan RI 2002 Basis, diagnosis and treatment of immunological infertility in men. Journal of Reproductive Immunology 57:35–45

    Article  CAS  PubMed  Google Scholar 

  • Matzinger P 2002 The danger model: A renewed sense of self. Science 296:301–305

    Article  CAS  PubMed  Google Scholar 

  • Mellor AL, Munn DH 2000 Immunology at the maternal-fetal interface: lessons for the T cell tolerance and suppression. Annual Review of Immunology 18:367–391

    Article  CAS  PubMed  Google Scholar 

  • Merrell F 1997 Peirce, Signs and Meaning. Toronto University Press, Toronto

    Google Scholar 

  • Neuman Y 2004 Meaning making in the immune system. Perspectives in Biology and Medicine 47:317–328

    Article  PubMed  Google Scholar 

  • Neuman Y 2005a Meaning making in language and biology. Perspectives in Biology and Medicine 48:317–327

    Article  PubMed  Google Scholar 

  • Neuman Y 2005b Why do we need signs in biology? Rivisita di Biologia/Biology Forum 98:497–513

    Google Scholar 

  • Neuman Y 2006 Cryptobiosis: a new theoretical perspective. Progress in Biophysics and Molecular Biology 92:258–267

    Article  PubMed  Google Scholar 

  • Neuman Y (2007) Immune memory, immune oblivion: a lesson from Funes the memorious. Progress in Biophysics and Molecular Biology (submitted)

    Google Scholar 

  • Paton R 2002 Process, structure and context in relation to integrative biology. BioSystems 64:63–72

    Article  PubMed  Google Scholar 

  • Rosen SM 2004 What is a radical recursion? S.E.E.D. 4(1):38–57

    Google Scholar 

  • Saussure F de 1972 Course in General Linguistics. Trans. Harris R Duckworth, London

    Google Scholar 

  • Schwartz M et al. 1999 Innate and adaptive immune responses can be beneficial for CNS repair. Trends in Neuroscience 22:295–299

    Article  CAS  Google Scholar 

  • Shukman A (ed.) 1983 Bakhtin School Papers. RPT Publications, Oxford

    Google Scholar 

  • Tauber AI 1996 The Immune Self: Theory or metaphor? Cambridge University Press, Cambridge

    Google Scholar 

  • Tauber AI 1997 Historical and philosophical perspectives concerning immune cognition. Journal of the History of Biology 30:419–440

    Article  CAS  PubMed  Google Scholar 

  • Tauber AI 1998 Conceptual shifts in immunology: comments on the “two-way” paradigm. Theoretical Medicine and Bioethics 19:457–473

    Article  CAS  PubMed  Google Scholar 

  • Tauber AI 1999 The elusive immune self: a case of category errors. Perspectives in Biology and Medicine 42:459–474

    CAS  PubMed  Google Scholar 

  • Tauber AI 2002 The biological notion of self and non-self. Stanford Encyclopedia of Philosophy. Available at: http://plato.stanford.edu/entries/biology-self

  • Thibault PJ 2005 Saussure and beyond. Lecture one: Speech and writing: two distinct systems of sign. Available at: www.chass.utoronto.ca/epc/srb/cyber/thi1.html

  • Vaz NM, Varela FJ 1978 Self and non-sense: an organism-centered approach to immunology. Medical Hypotheses 4:231–267

    Article  CAS  PubMed  Google Scholar 

  • Volosinov VN 1986 Maximum and the Philosophy of Language. Harvard University Press, Cambridge, MA

    Google Scholar 

  • Abbreviations of Peirce’s writings:

    Google Scholar 

  • Peirce, C. S

    Google Scholar 

  • MS xxx (number) = Peirce manuscripts

    Google Scholar 

  • CP x.xxx (volume.paragraph) = Collected Papers of Charles Sanders Peirce, 8 volumes. Vols 1–6, Charles Hartshorne and Paul Weiss (ed.), vols. 7–8, Arthur W. Burks (ed.) Harvard University Press, Cambridge, Massachusetts, pp. 1931–1958

    Google Scholar 

  • EP x:xxx (volume:page number) = The Essential Peirce. Selected Philosophical Writings. Vol. 1 (1867–1893), Nathan Houser & Christian Kloesel (eds), 1992, vol. 2 (1893–1913), Peirce Edition Project (ed.), 1998. Indiana University Press, Bloomington/Indianapolis

    Google Scholar 

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Neuman, Y. (2008). The Immune Self Code: From Correspondence to Complexity. In: Barbieri, M., Hoffmeyer, J. (eds) The Codes of Life. Biosemiotics, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6340-4_11

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