Post-Radiated and Post-Stressed Volatile Secretions: Secondary Immune and Behavioral Reactions in Groups of Animals

Conference paper
Part of the NATO Science for Peace and Security Series book series (NAPSC)

It was shown that the irradiated mice gave off with urine immunosuppressive components which possessed of high volatility. With their help even the one irradiated individual can induce in intact mice the disturbance of immunity and alteration of number of blood cells. Moreover, the predominant mouse from exposed group of mice also was capable to elicit disturbance of immunity in next group of intact animals. The same effects could be received by transfer of the urine samples from irradiated mice or from intact mice exposed with urine of irradiated animals to the box with intact individuals. It was established that ionizing radiation (4–6 Gy) of male mice increase their scent attractiveness to intact singenic male conspecifics. The carried out experiments have shown existence of the mediated by volatile chemosignals mechanism of multiplication second post-radiated disturbances of immunity in the groups of animals. The immunosuppressive volatile components were induced also by stress and some immunodepressants (dexametasone and cyclophosphamide).


Volatile Component Bystander Effect Irradiate Mouse Intact Mouse Stressed Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Barnett, S.A., 1975, The rat: A study in behavior. University of Chicago Press, Chicago, USA.Google Scholar
  2. Bures, J., Buresova, O., and Huston, J.P., 1983, Techniques and basic experiments for the study of brain and behavior. Amsterdam, New York.Google Scholar
  3. Halpin, Z.T., 1986, Individual odors among mammals origins and function. Adv. Stud. Behav. 16: 39–70.CrossRefGoogle Scholar
  4. Moshkin, M.P., Gerlinskaya, L., Morosova, O., Bakhvalova, V., and Evsikov, V., 2002, Behaviour, chemosignals and endocrine functions in male mice infected with tick-borne encephalitis virus. Psychoneuroendocrinology 27: 603–608.CrossRefGoogle Scholar
  5. Mothersill, C. and Seymour, C.B., 1998, Cell-cell contact during gamma-irradiation is not required to induce a bystander effect in normal human keratinocytes: evidence for release of a survival controlling signal into medium. Radiat. Res. 149: 256–262.CrossRefGoogle Scholar
  6. Mothersill, C. and Seymour, C.B., 2000, Genomic Instability, bystander effects & Radiation Risks: Implications for the development of Protection Strategies for man & the environment. Radiat. Biol. Radioecol. 40(5): 615–620 (in Russian).Google Scholar
  7. Mothersill, C. and Seymour, C.B., 2001, Radiation-induced bystander effects: past history and future directions. Radiat. Res. 155: 759–767. Review.CrossRefGoogle Scholar
  8. Penn, D.J. and Potts, W.K., 1998, Chemical signals and parasite-mediated sexual selection. Trends Ecol. Evol. 13: 391–396.CrossRefGoogle Scholar
  9. Surinov, B.P. and Dukhova, N.N., 2004, Postradiation mice’s volatile secretions which are attractive for intact individuals. Radiat. Biol. Radioecol. 44(6): 662–665 (in Russian).Google Scholar
  10. Surinov, B.P., Isaeva, V.G., and Dukhova, N.N., 2005, Post-radiation immunosuppressing and attractive volatile secretions: “Bystander effect” or allelopathy in groups of animals. Proc. Russian Acad. Sci. 400(5): 711–713 (in Russian).Google Scholar
  11. Surinov, B.P., Karpova, N.A., Isayeva, V.G., and Kulish, Y.S., 1998, Natural secretions in the post-radiation period and contact induction of immunodeficiency. Radiat. Biol. Radioecol. 38(1): 9–13 (in Russian).Google Scholar
  12. Yamazaki, K., Beauchamp, G.K., Singer, A.J., and Boyse, E.A., 1999, Odortypes: their origin and composition. Proc. Natl. Acad. Sci. USA 96:1522–525.CrossRefGoogle Scholar
  13. Zalcman, S., Kerr, L., Anisman, H., 1991, Immunosuppression elicited by stressors and stressor-related odors. Brain Behav. Immun. 5(3): 262–273.CrossRefGoogle Scholar

Copyright information

© Springer 2007

Authors and Affiliations

  1. 1.Medical Radiological Research Center of the Russian Academy of Medical SciencesKaluga RegionRussia

Personalised recommendations