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Radiation, Oxidative Stress and Senescence; The Vascular Endothelial Cell as a Common Target

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Multiple Stressors: A Challenge for the Future

Part of the book series: NATO Science for Peace and Security Series ((NAPSC))

Much evidence exists to implicate the endothelial cell as an important target for radiation in vivo. The nature and delayed manifestation of radiation damage to the endothelium is consistent with the induction of stress associated premature senescence (SIPS) a phenomenon known to occur in response to many types of oxidative stress. We propose the hypothesis that, particularly at low dose levels, induction of SIPS is the most important form of cellular damage sustained by the endothelium, and that this may be exacerbated by additional inducers of oxidative stress such as heavy metals and other pollutants. This paradigm raises new possibilities for therapies designed to slow or reverse endothelial cell senescence as part of the long term treatment for radiation exposure.

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Authors and Affiliations

  1. Department of Physiology, Development and Neuroscience, University of Cambridge, UK

    Paul N. Schofield & Jose Garcia-Bernardo

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  1. Paul N. Schofield
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  2. Jose Garcia-Bernardo
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Editors and Affiliations

  1. McMaster University, 1280 Main Street W, L8S 4K1, Hamilton, Canada

    Carmel Mothersill  & Colin Seymour  & 

  2. Institute of Genetics and Cytology National Academy of Sciences of Belarus, Akademicheskaya 27, 220072, Minsk, Belarus

    Irma Mosse

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Schofield, P.N., Garcia-Bernardo, J. (2007). Radiation, Oxidative Stress and Senescence; The Vascular Endothelial Cell as a Common Target. In: Mothersill, C., Mosse, I., Seymour, C. (eds) Multiple Stressors: A Challenge for the Future. NATO Science for Peace and Security Series. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6335-0_22

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