For the last 15 years, we have investigated low dose radiation genetic effects on human populations affected by the Chernobyl accident. Cytogenetic longitudinal investigations showed that amount of radiation markers for clean-up workers remained at the elevated level and had trend to grow up with the time. A dynamic profile of the amount of aberrations confirms that this group has symptoms of the genomic instability. State of the genomic instability correlates with accumulation of clastogenic factors, responsible for increased genomic instability in clean-up workers peripheral blood. As a model for clastogenic activity testing, we used human keratinocyte cell line with blocked 1st check point of cell cycle. Our results confirm that cytogenetic and molecular effects of irradiation can be fixed even 20 years after the Chernobyl accident.
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Melnov, S., Marozik, P., Drozd, T. (2007). Clastogenic Factors, Bystander Effects and Genomic Instability In Vivo. In: Mothersill, C., Mosse, I., Seymour, C. (eds) Multiple Stressors: A Challenge for the Future. NATO Science for Peace and Security Series. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6335-0_12
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