Clastogenic Factors, Bystander Effects and Genomic Instability In Vivo
- 699 Downloads
For the last 15 years, we have investigated low dose radiation genetic effects on human populations affected by the Chernobyl accident. Cytogenetic longitudinal investigations showed that amount of radiation markers for clean-up workers remained at the elevated level and had trend to grow up with the time. A dynamic profile of the amount of aberrations confirms that this group has symptoms of the genomic instability. State of the genomic instability correlates with accumulation of clastogenic factors, responsible for increased genomic instability in clean-up workers peripheral blood. As a model for clastogenic activity testing, we used human keratinocyte cell line with blocked 1st check point of cell cycle. Our results confirm that cytogenetic and molecular effects of irradiation can be fixed even 20 years after the Chernobyl accident.
KeywordsGenomic Instability Bystander Effect Chernobyl Accident Aberration Frequency Acute Virus Infection
Unable to display preview. Download preview PDF.
- Kash, J.C., Basler, C.F., Garcia-Sastre, A., Carter, V., Billharz, R., Swayne, D.E., Przygodzki, R.M., Taubennerger, J.K., Katze, M.G., and Tumpey, T.M., 2004, Global host immune response: pathogenesis and transcriptional profiling of type A influenza viruses expressing the hemagglutinin and neuraminidase genes from the 1918 pandemic virus, J Virol 78 (17):9499–511.CrossRefGoogle Scholar
- Melnov, S.B., 2004, Molecular and Genetic Effects of Ecological Trouble (Possibilities of Flow Cytometry), Committee “Chernobyl children”, Minsk, pp. 10–32.Google Scholar
- Nagasawa, H. and Little, J.B., 1992, Induction of sister chromatid exchanges by extremely low doses of alpha-particles, Cancer Res 52:6394–396.Google Scholar