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Rhomboid Intramembrane Serine Proteases

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Book cover Intramembrane-Cleaving Proteases (I-CLiPs)

Part of the book series: Proteases in Biology and Disease ((PBAD,volume 6))

Abstract

Intramembrane proteolysis catalyzed by rhomboid proteases plays key roles in such diverse cell communication events as receptor tyrosine kinase signalling during animal development, and quorum sensing during bacterial growth. In these contexts, rhomboid proteins act in the signal-sending cell to activate signal precursor proteins and initiate the signalling event. Recent biochemical advances have culminated in the first high-resolution crystal structures of an intramembrane protease, and a pure enzyme reconstitution system for studying rhomboid activity. Functional studies have expanded the cellular role of rhomboid proteins to broad biological processes, including host-cell invasion by malaria parasites, which is the first implication of these enzymes as possible therapeutic targets in human disease

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Authors and Affiliations

  1. Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Sinisa Urban

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  1. University of Leeds, Leeds, United Kingdom

    Nigel M. Hooper

  2. Otto-von-Guericke Universität, Magdeburg, Germany

    Uwe Lendeckel

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Urban, S. (2007). Rhomboid Intramembrane Serine Proteases. In: Hooper, N.M., Lendeckel, U. (eds) Intramembrane-Cleaving Proteases (I-CLiPs). Proteases in Biology and Disease, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6311-4_4

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