Skip to main content
SpringerLink
Log in
Book cover

Pluralistic Casuistry pp 149–165Cite as

A Matter of Obligation: Physicians Versus Clinical Investigators

  • Chapter

  • 430 Accesses

Part of the book series: Philosophy and Medicine ((PHME,volume 94))

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Angell, M. (1997). ‘The ethics of clinical research in the Third World,’ The New England Journal of Medicine, 337, 847–49.

    Article  Google Scholar 

  • Ancheff v. Hartford Hospital, 799 A2d 1067 (Conn. 2002).

    Google Scholar 

  • Appelbaum, P.S. (2002). ‘Clarifying the ethics of clinical research: a path toward avoiding the therapeutic misconception,’ The American Journal Of Bioethics, 2(2), 22–23.

    Article  Google Scholar 

  • Appelbaum, P.S., Lidz, C.W., & Grisso, T. (2004). ‘Therapeutic misconception in clinical research: frequency and risk factors,’ IRB, 26(2), 1–8.

    Article  Google Scholar 

  • Appelbaum, P.S., Roth, L.H., & Lidz, C. (1982). ‘The therapeutic misconception: informed consent in psychiatric research,’ International Journal of Law & Psychiatry, 5(3-4), 319–329.

    Article  Google Scholar 

  • Appelbaum, P.S., Roth, L.H., Lidz, C.W., Benson, P., & Winslade, W. (1987). ‘False hopes and best data: consent to research and the therapeutic misconception,’ Hastings Center Report, 17(2), 20–24.

    Article  Google Scholar 

  • Brody, B.A. (1995). Ethical Issues in Drug Testing, Approval, and Pricing: The Clot-Dissolving Drugs (pp. 112–131). New York: Oxford.

    Google Scholar 

  • Brody, B. (2003). Taking Issue: Pluralism and Casuistry in Bioethics. Washington, D.C.: Georgetown University Press.

    Google Scholar 

  • Calhoun v. Rane, 599 N.E.2d 1318 (III.App 1 Dist. 1992).

    Google Scholar 

  • Collins v Nugent, 443 NE2d 277 (Ill. App. 1 Dist. 1982).

    Google Scholar 

  • Cooter, R., & Freedman, B.J. (1991). ‘The fiduciary relationship: its economic character and legal consequences,’ New York University Law Review, 66, 1045–1075.

    Google Scholar 

  • Coughlin v. SeRine, 507NE2d 505 (III.App. Dist. 1987).

    Google Scholar 

  • Craft v. Vanderbilt Univ., 18 F.Supp.2d 786 (M.D. Tenn 1998).

    Google Scholar 

  • Davis, K.B., Jr. (1986). Judicial review of fiduciary decisionmaking—some theoretical perspectives,’ Northwestern University Law Review, 80, 1–99.

    Google Scholar 

  • DeMott, D.A. (1988). ‘Beyond metaphor: an analysis of fiduciary obligation,’ Duke Law Journal, 819, 879-924.

    Article  Google Scholar 

  • Doe v. Roe, 681 NE2d 640, 646 (III.App.1 Dist. 1997).

    Google Scholar 

  • Emanuel, E.J., Wendler, D., & Grady, C. (2000). What makes clinical research ethical? Journal of the American Medical Association, 283, 2701–2711.

    Article  Google Scholar 

  • Emanuel, E.J., & Miller, F.G. (2001). ‘The ethics of placebo controlled trials—a middle ground,’ The New England Journal of Medicine, 345(12), 915–19.

    Article  Google Scholar 

  • Finn, P.D. (1977). Fiduciary Obligations. Sydney: The Law Book Company Limited.

    Google Scholar 

  • Frankel, T. (1983). ‘Fiduciary law,’ California Law Review, 71, 795–836.

    Article  Google Scholar 

  • Freedman, B., Weijer, C., & Glass, K.C. (1996). ‘Placebo orthodoxy in clinical research II: ethical, legal, and regulatory myths,’ The Journal of Law, Medicine, & Ethics, 24, 252–59.

    Article  Google Scholar 

  • Glass, K.C. (2003). ‘Clinical equipoise and the therapeutic misconception,’ Hastings Center Report, 33(5), 5-6.

    Google Scholar 

  • Grunberg, S.M., & Cefalu, W.T. (2003). ‘The integral role of clinical research in clinical care,’ The New England Journal of Medicine, 348, 1386–88.

    Article  Google Scholar 

  • Holder, A.R. (1982). ‘Do researchers and subjects have a fiduciary relationship?’ IRB, 4(1), 6-7.

    Article  Google Scholar 

  • Jacobson, P.D. & Cahill, M.T. (2000). ‘Applying fiduciary responsibilities in the managed care context,’ American Journal of Law & Medicine, 26, 155–173.

    Google Scholar 

  • Kovach, K. ‘Distinguishing dilemmas in the ethics of placebo-controlled trials,’ The American Journal of Bioethics, 2(2), 32–33.

    Google Scholar 

  • Lerner, B.H. (2004). ‘Sins of omission–cancer research without informed consent,’ The New England Journal of Medicine, 351, 628–30.

    Article  Google Scholar 

  • Levine, R.J. (2002). ‘Placebo controls in clinical trials of new therapies for conditions for which there are known effective treatments,’ in H.A. Guess, A. Lkeinman, J.W. Kusek, L.W. Engel (eds.). The Science of the Placebo: Toward an Interdisciplinary Research Agenda. London: BMJ Books, pp. 264–280.

    Google Scholar 

  • Lockett v. Goodill 430 P.2d 589, 591 (Wash. 1967)

    Google Scholar 

  • Lownsbury v. VanBuren, 762 N.E.2d 354 (Ohio 2002).

    Google Scholar 

  • Mann, H. (2002). ‘Therapeutic beneficence and Patient recruitment in randomized controlled clinical trials,’ The American Journal of Bioethics, 2(2), 35–36.

    Article  Google Scholar 

  • Mann, H., & Djulbegovic, B. (2003). ‘Clinical equipoise and the therapeutic misconception,’ Hastings Center Report, 33(5), 4–5.

    Article  Google Scholar 

  • Meinhard v. Salmon, 164 N.E. 545 (N.Y. 1928).

    Google Scholar 

  • Miller v. Kennedy, 522 P.2d 852, 860-61 (Wash. Ct. App. 1974), aff’d, 530 P.2d 334 (Wash. 1975).

    Google Scholar 

  • Miller, F.G. (2004). ‘Research ethics and misguided moral intuition,’ Journal of Law, Medicine & Ethics, 32, 111–116.

    Article  Google Scholar 

  • Miller, F.G., & Brody, H. (2002). ‘What makes placebo-controlled trials unethical?’ The American Journal of Bioethics, 2(2), 3–9.

    Article  Google Scholar 

  • Miller, F.G., & Brody, H. (2003). ‘A critique of clinical equipoise: therapeutic misconception in the ethics of clinical trials,’ Hastings Center Report, 33(3), 19–28.

    Article  Google Scholar 

  • Miller, F.G., & Rosenstein, D.L. (2003). ‘The therapeutic orientation to clinical trials,’ The New England Journal of Medicine, 348, 1383–86.

    Article  Google Scholar 

  • Miller, P.B., & Weijer, C. (2003). ‘Rehabilitating equipoise,’ Kennedy Institute of Ethics Journal, 12, 94–118.

    Google Scholar 

  • Moore v. Regents of the Univ. of Cal., 793 P.2d 479, 483 (Cal. 1990).

    Google Scholar 

  • Morin, K. (1998). ‘The standard of disclosure in human subject experimentation,’ The Journal of Legal Medicine, 19, 157-221.

    Article  Google Scholar 

  • Morreim, E.H. (2003). ‘Medical research litigation and malpractice tort doctrines: courts on a learning curve,’ Houston Journal of Health Law and Policy, 4(1), 1–86.

    Google Scholar 

  • Morreim, E.H. (2005). ‘The clinical investigator as fiduciary: Discarding a misguided idea,’ Journal of Law, Medicine & Ethics, 33(3), 586–598.

    Article  Google Scholar 

  • National Placebo Working Committee (2003). National Placebo Initiative, Draft Report. October 2003 [On-line] Available: http://www.cihr-irsc.gc.ca/e/services/pdf_19320.htm, at 37.

    Google Scholar 

  • Nozick, R. (1974). Anarchy, State, and Utopia. New York: Basic Books, Inc.

    Google Scholar 

  • Payette v. Rockefeller Univ., 643 N.Y.S.2d 79 (App Div 1 Dept. 1996).

    Google Scholar 

  • Rodwin, M.A. (1995). ‘Strains in the fiduciary metaphor: divided physician loyalties and obligations in a changing health care system,’ American Journal of Law & Medicine, 21, 241–257.

    Google Scholar 

  • Rothman, K.J., & Michels, K.B. (1994). ‘The continuing unethical use of placebo controls,’ The New England Journal of Medicine, 331, 394–98.

    Article  Google Scholar 

  • Saver, R.S. (1996). ‘Critical care research and informed consent,’ North Carolina Law Review, 75, 205–271.

    Google Scholar 

  • Scott, A.W. (1949). ‘The fiduciary principle,’ California Law Review, 4, 539–55.

    Article  Google Scholar 

  • Scott, A.W. (1967). The Law of Trusts, Third edition (pp. 34–49). Boston: Little, Brown and Company.

    Google Scholar 

  • Scott v. Dime Sav. Bank of New York, FSB, 886 F.Supp. 1073, 1078 (S.D.N.Y. 1995), affd w/o opin. 101 F.3d 107 (2d Cir. 1996), cert. denied 520 U.S. 1122 (1997)

    Google Scholar 

  • Shadrick v Coker, 963 SW2d 726, 735 (Tenn 1998).

    Google Scholar 

  • Shepherd, J.C. (1981). The Law of Fiduciaries. Toronto: The Carswell Company Limited.

    Google Scholar 

  • Steinberg, D. (2002). ‘Clinical research should not be permitted to escape the ethical orbit of clinical care,’ The American Journal of Bioethics, 2(2), 27–28.

    Article  Google Scholar 

  • Vodopest v. MacGregor, 913 P.2d 779 (Wash. 1996).

    Google Scholar 

  • Weijer, C. (2000). ‘The ethical analysis of risk,’ The Journal of Law, Medicine & Ethics : A Journal of the American Society of Law, Medicine & Ethics, 28, 344–61.

    Article  Google Scholar 

  • Weijer, C. (2002). ‘When argument fails,’ American Journal of Bioethics, 2(2), 10–11.

    Article  Google Scholar 

  • Weijer, C. & Miller, P.B. (2004). ‘When are research risks reasonable in relation to anticipated benefits?’ Nature Medicine, 10, 570–73.

    Article  Google Scholar 

  • Weijer, C., Shapiro, S.H., Glass, K.C., & Enkin, M. (2000). ‘For and against: clinical equipoise and not the uncertalinty principle is the moral underpinning of the randomised controlled trial,’ British Medical Journal, 321, 756–58.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Health Science Center, The University of Tennessee, Memphis, Tennessee, U.S.A.

    E. Haavi Morreim

Authors
  1. E. Haavi Morreim
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Philosophy, St. Edward’s University, Austin, Texas

    Mark J. Cherry

  2. Center for Health Care Ethics, Saint Louis University, St. Louis, Missouri

    Ana Smith Iltis

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer

About this chapter

Cite this chapter

Morreim, E.H. (2007). A Matter of Obligation: Physicians Versus Clinical Investigators. In: Cherry, M.J., Iltis, A.S. (eds) Pluralistic Casuistry. Philosophy and Medicine, vol 94. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6260-5_10

Download citation

Publish with us

Policies and ethics

Search

Navigation