Gelsolin and Diseases

  • L. SPINARDI
  • W. WITKE
Part of the Subcellular Biochemistry book series (SCBI, volume 45)

Abstract

Gelsolin is a calcium-activated actin filament severing and capping protein found in many cell types and as a secreted form in the plasma of vertebrates. Mutant mice for gelsolin as well as clinical studies have shown that gelsolin is linked to a number of pathological conditions such as inflammation, cancer and amyloidosis. The tight regulation of gelsolin by calcium is crucial for its physiological role and constitutive activation leads to apoptosis. In the following we will give an overview on how gelsolin is regulated by calcium, and which clinical conditions have been linked to lack or misregulation of gelsolin

Keywords

Gelsolin calcium diseases amyloidosis inflammation cancer 

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Copyright information

© Springer 2007

Authors and Affiliations

  • L. SPINARDI
    • 1
  • W. WITKE
    • 2
  1. 1.Direzione ScientificaIRCCS Fondazione Ospedale Policlinico, Mangiagalli e Regina ElenaViaFrancesco Sforza 28Italy
  2. 2.EMBL MonterotondoVia Ramarini 32, 00015 MonterotondoItaly

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