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Calcium and Cardiomyopathies

  • Chapter
Calcium Signalling and Disease

Part of the book series: Subcellular Biochemistry ((SCBI,volume 45))

Abstract

Regulation of Calcium (Ca) cycling by the sarcoplasmic reticulum (SR) underlies the control of cardiac contraction during excitation-contraction (E-C) coupling. Moreover, alterations in E-C coupling occurring in cardiac hypertrophy and heart failure are characterized by abnormal Ca-cycling through the SR network. A large body of evidence points to the central role of: a) SERCA and its regulator phospholamban (PLN) in the modulation of cardiac relaxation; b) calsequestrin in the regulation of SR Ca-load; and c) the ryanodine receptor (RyR) Ca-channel in the control of SR Ca-release. The levels or activity of these key Ca-handling proteins are altered in cardiomyopathies, and these changes have been linked to the deteriorated cardiac function and remodeling. Furthermore, genetic variants in these SR Ca-cycling proteins have been identified, which may predispose to heart failure or fatal arrhythmias. This chapter concentrates on the pivotal role of SR Ca-cycling proteins in health and disease with specific emphasis on their recently reported genetic modifiers

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Authors and Affiliations

  1. Department of Pharmacology and Cell Biophysics,College of Medicine, University of Cincinnati, Cincinnati, OH 45267, U.S.A

    E.G. KRANIAS

  2. Department of Physiology, Loyola University,Chicago, Stritch School of Medicine, Maywood, IL 60153, U.S.A

    D.M. BERS

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  1. E.G. KRANIAS
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Editors and Affiliations

  1. University of Padova, Padova, Italy

    Ernesto Carafoli

  2. University of Padova, Padova, Italy

    Marisa Brini

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KRANIAS, E., BERS, D. (2007). Calcium and Cardiomyopathies. In: Carafoli, E., Brini, M. (eds) Calcium Signalling and Disease. Subcellular Biochemistry, vol 45. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6191-2_20

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