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Crimean-Congo Hemorrhagic Fever pp 143–154Cite as

Role of Ticks in the Transmission of Crimean-Congo Hemorrhagic Fever Virus

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Ticks were suspected of transmitting Crimean-Congo hemorrhagic fever (CCHF) virus (CCHFV) shortly after the disease was formally described in the mid-1940s [6], and inoculation of tick suspensions into human volunteers confirmed that ticks contained a filterable agent that caused CCHF [5, 6, 8,]. Initial epidemiological studies indicated that cases of this newly described disease occurred during the spring and summer; cases were often sporadic with no direct contact between patients; nearly all of the patients had a history of a recent tick bite; and there was little evidence of mosquito, sand fly, or other insect bites among these patients [6]. Studies conducted since then have consistently found a relationship between various tick species and the presence of CCHFV, and ticks are believed to be the principal means of viral transmission and persistence in nature [4, 8, 17, 43]. CCHFV has been detected in or isolated from>30 species of ticks (Table 12-1). In addition, CCHFV has been isolated from Culicoides species flies on at least two occasions [3, 25]. However, the mere isolation of a virus from an arthropod does not mean that the arthropod is involved in the natural transmission of that virus.

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References

  1. Ardoin P (1965) Congo group transmission experiments. Rep E Afr Virus Res Inst 14:52.

    Google Scholar 

  2. Berezin VV, Chumakov PM, Reshetknikov IA, Zgurskaya GN (1971) Study of the role of birds in the ecology of Crimean hemorrhagic fever virus. Mater 6 Simp Izuch Virus Ekol Svyazan Ptits (Omsk, 1971):94–95 (in Russian) (in English, NAMRU3–T721).

    Google Scholar 

  3. Causey OR, Kemp GE, Madbouly MH, David-West TS (1970) Congo virus from domestic livestock, African hedgehog, and arthropods in Nigeria. Am J Trop Med Hyg 19:846–850.

    PubMed  CAS  Google Scholar 

  4. Camicas JL, Cornet JP, Gonzalez JP, Wilson ML, Adam F, Zeller HG (1994) Crimean-Congo hemorrhagic fever in Senegal. Latest data on the ecology of the CCHF virus. Bull Soc Pathol Exot 87:11–16 (in French).

    PubMed  CAS  Google Scholar 

  5. Casals J (1978) Crimean-Congo hemorrhagic fever. In: Pattyn SR (ed.) Ebola virus hemorrhagic fever. Elsevier/North-Holland Biomedical Press, Amsterdam, The Netherlands, pp 301–317.

    Google Scholar 

  6. Chumakov, MP (1947) A new viral disease-Crimean hemorrhagic fever. Nov Med 4:9–11 (in Russian) (in English, NAMRU3–T900).

    Google Scholar 

  7. Chumakov MP, Butenko AM, Rubin SG, Berezin VV, Karinskaya GA, Vasilenko SM, Smirnova SE, Bashkirtsev VV, Derbedeneva MP, Badalov ME, Stolbov DN (1972) Question on the ecology of Crimean hemorrhagic fever (CHF) virus. In: Cherepanov AI (ed) Transcontinental connections of migratory birds and their role in distribution of arboviruses. Mater 5 Simp Izuch Roli Pereletn Ptitsepererab Rasprostr Arbovirus, Novosibirsk, pp 222–229 (In Russian) (In English, NAMRU3–T877).

    Google Scholar 

  8. Chumakov, MP (1974) On 30 years of investigation of Crimean hemorrhagic fever. Tr Inst Polio Virusn Entsefalitov Akad Med Nauk SSSR 22:5–18 (in Russian) (in English, NAMRU3–T950).

    Google Scholar 

  9. Dickson DL, Turell MJ (1992) Replication and tissue tropisms of Crimean-Congo hemorrhagic fever virus in experimentally infected adult Hyalomma truncatum (Acari: Ixodidae). J Med Entomol 29:767–773.

    PubMed  CAS  Google Scholar 

  10. Dohm DJ, Logan TM, Linthicum KJ, Rossi CA, Turell MJ (1996) Transmission of Crimean-Congo hemorrhagic fever virus by Hyalomma impeltatum (Acari:Ixodidae) after experimental infection. J Med Entomol 33:848–851.

    PubMed  CAS  Google Scholar 

  11. Durden LA, Logan TM, Wilson ML, Linthicum KJ (1993) Experimental vector incompetence of a soft tick, Ornithodoros sonrai (Acari: Argasidae), for Crimean-Congo hemorrhagic fever virus. J Med Entomol 30:493–496.

    PubMed  CAS  Google Scholar 

  12. Ebel GD, Kramer LD (2004) Duration of tick attachment required for transmission of Powassan virus by deer ticks. Am J Trop Med Hyg 71:268–271.

    PubMed  Google Scholar 

  13. Faye O, Cornet JP, Camicas JL, Fontenille D, Gonzalez JP (1999) Experimental transmission of Crimean-Congo hemorrhagic fever virus: role of 3 vector species in the maintenance and transmission cycles in Senegal (Article in French). Parasite 6:27–32.

    PubMed  CAS  Google Scholar 

  14. Faye O, Fontenille D, Thonnon J, Gonzalez JP, Cornet JP, Camicas JL (1999) Experimental transmission of Crimean-Congo hemorrhagic fever virus by Rhipicephalus evertsi evertsi (Acarina:Ixodidae) (Article in French). Bull Soc Pathol Exot 92:143–147.

    PubMed  CAS  Google Scholar 

  15. Gonzalez JP, Camicas JL, Cornet JP, Faye O, Wilson ML (1992) Sexual and transovarian transmission of Crimean-Congo haemorrhagic fever virus in Hyalomma truncatum ticks. Res Virol 143:23–28.

    Article  PubMed  CAS  Google Scholar 

  16. Gordon SW, Linthicum KJ, Moulton JR (1993) Transmission of Crimean-Congo hemorrhagic fever virus in two species of Hyalomma ticks from infected adults to cofeeding immature forms. Am J Trop Med Hyg 48:576–580.

    PubMed  CAS  Google Scholar 

  17. Hoogstraal H (1979) The epidemiology of tick-borne Crimean-Congo hemorrhagic fever in Asia, Europe, and Africa. J Med Entomol 15:307–417.

    PubMed  CAS  Google Scholar 

  18. Horak IG, Camicas J-L, Keirans JE (2002) The Argasidae, Ixodidae and Nuttalliellidae (Acari: Ixodida): a world list of valid tick names. Exp Appl Acarol 28:27–54.

    Article  PubMed  Google Scholar 

  19. Jones LD, Davies CR, Steele GM, Nuttall PA (1987) A novel mode of arbovirus transmission involving a nonviremic host. Science 237:775–777.

    Article  PubMed  CAS  Google Scholar 

  20. Katavolos P, Armstrong PM, Dawson JE, Telford SR III (1998) Duration of tick attachment required for transmission of granulocytic ehrlichiosis. J Infect Dis 177:1422–1425.

    Article  PubMed  CAS  Google Scholar 

  21. Kondratenko VF (1976) Importance of ixodid ticks in transmitting and preserving the Crimean hemorrhagic fever agent in infection foci. Parazitologiya 10:297–302 (in Russian) (in English, NAMRU3–T1116).

    CAS  Google Scholar 

  22. Kondratenko VF, Blagoveshchenskaya NM, Butenko AM, Rubin SG, Berezin VV, Vishnivetskaya LK, Zarubina LV, Milyutin VN, Kuchin VV, Novikova EM, Rabinovich VD, Shevchenco SF, Chumakov MP (1970) Results of virological investigation of ixodid ticks in Crimean hemorrhagic fever focus in Rostov Oblast. In: Chumakov MP (ed.) Crimean Hemorrhagic Fever. Mater 3 Oblast Nauch Prakt Konf, Rostov-na-Donu, pp 29–35 (in Russian) (in English, NAMRU3–T524).

    Google Scholar 

  23. Labuda M, Jones LD, Williams T, Danielova V, Nuttall PA (1993) Efficient transmission of tick-borne encephalitis virus between cofeeding ticks. J Med Entomol 30:295–299.

    PubMed  CAS  Google Scholar 

  24. Labuda M, Kozuch O, Zuffova E, Eleckova E, Hails RS, Nuttall PA (1997) Tick-borne encephalitis virus transmission between ticks cofeeding on specific immune natural rodent hosts. Virology 235:138–143.

    Article  PubMed  CAS  Google Scholar 

  25. Lee VH (1979) Isolation of viruses from field populations of Culicoides (Diptera: Ceratopogonidae) in Nigeria. J Med Entomol 16:76–79.

    PubMed  CAS  Google Scholar 

  26. Lee VH, Kemp GE (1970) Congo virus: experimental infection of Hyalomma rufipes and transmission to a calf. Bull Entomol Soc Nigereria 2:133–135.

    Google Scholar 

  27. Logan TM, Linthicum KJ, Bailey CL, Watts DM, Moulton JR (1989) Experimental transmission of Crimean-Congo hemorrhagic fever virus by Hyalomma truncatum Koch. Am J Trop Med Hyg 40:207–212.

    PubMed  CAS  Google Scholar 

  28. Logan TM, Linthicum KJ, Bailey CL (1990) Replication of Crimean-Congo hemorrhagic fever virus in four species of ixodid ticks (Acari) infected experimentally. J Med Entomol 27:537–542.

    PubMed  CAS  Google Scholar 

  29. L'vov DN, Dzharkenov AF, Aristova VA, Kovtunov AI, Gromashevskii VL, Vyshemirskii OI, Galkina IV, Larichev VF, Butenko AM, L'vov DK (2002) The isolation of Dhori viruses (Orthomyxoviridae, Thogotovirus) and Crimean-Congo hemorrhagic fever virus (Bunyaviridae, Nairovirus) from the hare (Lepus europaeus) and its ticks Hyalomma marginatum in the middle zone of the Volga delta, Astrakhan region, 2001 (Article in Russian). Vopr Virusol 47:32–36.

    PubMed  Google Scholar 

  30. Okorie TG (1991) Comparative studies on the vector capacity of the different stages of Amblyomma variegatum Fabricius and Hyalomma rufipes Koch for Congo virus, after intracoelomic inoculation. Vet Parasitol 38:215–223.

    Article  PubMed  CAS  Google Scholar 

  31. Onishchenko GG, Tumanova IIu, Vyshemirskii OI, Kuhn J, Seregin SV, Tiunnikov GI, Petrova ID, Tishkova F, Ospanov KS, Kazakov SV, Karimov SK, Esmagambetova AS, Netesov SV, Petrov VS (2005) ELISA and RT-PCR-based research of viruses in the ticks collected in the foci of Crimean-Congo fever in Kazakhstan and Tajikistan in 2001–2002 (Article in Russian). Vopr Virusol 50:23–26.

    PubMed  CAS  Google Scholar 

  32. Onishchenko GG, Tumanova IIu, Vyshemirskii OI, Kuhn J, Seregin SV, Tiunnikov GI, Petrova ID, Tishkova FKh, Ospanov KS, Kazakov SV, Karimov SK, Esmagambetova AS, Netesov SV, Petrov VS (2005) Study of virus contamination of Ixodes ticks in the foci of Crimean-Congo hemorrhagic fever in Kazakhstan and Tajikistan (Article in Russian). Zh Mikrobiol Epidemiol Immunobiol 1:27–31.

    PubMed  Google Scholar 

  33. Peavey CA, Lane RS (1995) Transmission of Borrelia burgdorferi by Ixodes pacificus nymphs and reservoir competence of deer mice (Peromyscus maniculatus) infected by tick-bite. J Parasitol 81:175–178.

    Article  PubMed  CAS  Google Scholar 

  34. Piesman J, Mather TN, Sinsky RJ, Spielman A (1987) Duration of tick attachment and Borrelia burgdorferi transmission. J Clin Microbiol 25:557–558.

    PubMed  CAS  Google Scholar 

  35. Reeves WC (1957) Arthropods as vectors and reservoirs of animal pathogenic viruses. In: Hallauer C, Meyer KF (eds) Handbuch der Virusforschung, vol 4 (Suppl 3). Springer-Verlag, Vienna, pp 177–202.

    Google Scholar 

  36. Saluzzo JF, Digoutte JP, Camicas JL, Chauvancy G (1985) Crimean-Congo haemorrhagic fever and Rift Valley fever in south-eastern Mauritania. Lancet 1:116.

    Article  PubMed  CAS  Google Scholar 

  37. Shchelkanov MIu, Kolobukhina LV, Moskvina TM, Aushev ID, Kartoev AA, Kelli EI, Merkulova LN, Grenkova EP, Samokhvalov EI, Petriaev VG, Serobian AG, Klimova EA, Galkina IV, Malyshev NA, Aristova VA, Slavskii AA, Luk'ianova NA, Deriabin PG, Gromashevskii VL, Efremenko VI, Onishchenko GG, L'vov DK (2005) Detection of the circulation of Crimean-Congo hemorrhagic fever virus in the piedmont steppes of the North Caucasus (Article in Russian). Vopr Virusol 50:9–15.

    PubMed  Google Scholar 

  38. Shepherd AJ, Swanepoel R, Cornel AJ, Mathee O (1989) Experimental studies on the replication and transmission of Crimean-Congo hemorrhagic fever virus in some African tick species. Am J Trop Med Hyg 40:326–331.

    PubMed  CAS  Google Scholar 

  39. Shepherd AJ, Swanepoel R, Shepherd SP, Leman PA, Mathee O (1991) Viraemic transmission of Crimean-Congo haemorrhagic fever virus to ticks. Epidemiol Infect 106:373–382.

    Article  PubMed  CAS  Google Scholar 

  40. Stewart RL, Burgdorfer W, Needham GR (1998) Evaluation of three commercial tick removal tools. Wilderness Environ Med 9:137–142.

    PubMed  CAS  Google Scholar 

  41. Swanepoel R, Struthers JK, Shepherd AJ, McGillivray GM, Nel MJ, Jupp PG (1983) Crimean-Congo hemorrhagic fever in South Africa. Am J Trop Med Hyg 32:1407–1415.

    PubMed  CAS  Google Scholar 

  42. Tsilinsky YaYa, Lebedev AD, Pak TP, Gromashevsky VL, Timofeev EM, Ershov FI, Tsirkin YuM, L'vov DK (1972) Isolation of Crimean hemorrhagic fever (CHF) virus from Hyalomma plumbeum ticks in Tadzhikistan. Mater Simp Itogi 6 Simp Izuch Virus Ekol Svyazan Ptits (Omsk, 1971):94–97 (in Russian) (in English, NAMRU3–T665).

    Google Scholar 

  43. Watts DM, Ksiazek TG, Linthicum KJ, Hoogstraal H (1988) Crimean-Congo Hemorrhagic fever. In: Monath TP (ed.) The Arboviruses: Epidemiology and Ecology, vol 2. CRC Press, Boca Raton, FL, pp 177–222.

    Google Scholar 

  44. Williams RJ, Al-Busaidy S, Mehta FR, Maupin GO, Wagoner KD, Al-Awaidy S, Suleiman AJ, Khan AS, Peters CJ, Ksiazek TG (2000) Crimean-Congo haemorrhagic fever: a seroepidemiological and tick survey in the Sultanate of Oman. Trop Med Int Health 5:99–106.

    Article  PubMed  CAS  Google Scholar 

  45. Wilson ML, Gonzalez JP, Cornet JP, Camicas JL (1991) Transmission of Crimean-Congo haemorrhagic fever virus from experimentally infected sheep to Hyalomma truncatum ticks. Res Virol 142:395–404.

    Article  PubMed  CAS  Google Scholar 

  46. Yunker CE, Cory J (1975) Plaque production by arboviruses in Singh's Aedes albopictus cells. Appl Microbiol 29:81–89.

    PubMed  CAS  Google Scholar 

  47. Zeller HG, Cornet JP, Camicas JL (1994) Crimean-Congo haemorrhagic fever virus infection in birds: field investigations in Senegal. Res Virol 145:105–109.

    Article  PubMed  CAS  Google Scholar 

  48. Zeller HG, Cornet JP, Camicas JL (1994) Experimental transmission of Crimean-Congo hemorrhagic fever virus by West African wild ground-feeding birds to Hyalomma marginatum rufipes ticks. Am J Trop Med Hyg 50:676–681.

    PubMed  CAS  Google Scholar 

  49. Zeller HG, Cornet JP, Diop A, Camicas JL (1997) Crimean-Congo hemorrhagic fever in ticks (Acari: Ixodidae) and ruminants: field observations of an epizootic in Bandia, Senegal (1989–1992). J Med Entomol 34:511–516.

    PubMed  CAS  Google Scholar 

  50. Zgurskaya GN, Berezin VV, Smirnova SE, Chumakov MP (1971) Investigation of the question of Crimean hemorrhagic fever virus transmission and interepidemic survival in the tick Hyalomma plumbeum plumbeum Panzer. In: Chumakov MP (ed.) Viral hemorrhagic fevers. Crimean hemorrhagic fever, Omsk hemorrhagic fever, and hemorrhagic fever with renal syndrome. Trudy Inst Polio Virusn Entsefalitov Akad Med Nauk SSSR 19:217–220.

    Google Scholar 

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  1. Virology Division, Usamriid, 1425 Porter Street, Fort Detrick, 27702-5011, MD, USA

    Michael J. Turell Ph.D

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  1. Michael J. Turell Ph.D
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  1. Marmara University, School of Medicine, Altunizade, Istanbul, Turkey

    Onder Ergonul M.D., M.P.H

  2. Usamriid, Fort Detrick, 21702-5011, Frederick, MD, USA

    Chris A. Whitehouse Ph.D

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Turell, M.J. (2007). Role of Ticks in the Transmission of Crimean-Congo Hemorrhagic Fever Virus. In: Ergonul, O., Whitehouse, C.A. (eds) Crimean-Congo Hemorrhagic Fever. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6106-6_12

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