McKenna, K., A.S. Beignon, and N. Bhardwaj, Plasmacytoid dendritic cells: linking innate and adaptive immunity. J Virol, 2005. 79(1): p. 17–27.
PubMed
CAS
Google Scholar
Shortman, K. and Y.J. Liu, Mouse and human dendritic cell subtypes. Nat Rev Immunol, 2002. 2(3): p. 151–61.
PubMed
CAS
Google Scholar
Ebner, S., et al., Expression of C-type lectin receptors by subsets of dendritic cells in human skin. Int Immunol, 2004. 16(6): p. 877–87.
PubMed
CAS
Google Scholar
Rafiq, K., A. Bergtold, and R. Clynes, Immune complex-mediated antigen presentation induces tumor immunity. J Clin Invest, 2002. 110(1): p. 71–9.
PubMed
CAS
Google Scholar
Albert, M.L., et al., Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J Exp Med, 1998. 188(7): p. 1359–68.
PubMed
CAS
Google Scholar
Bonifaz, L., et al., Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J Exp Med, 2002. 196(12): p. 1627–38.
PubMed
CAS
Google Scholar
Peiser, L., S. Mukhopadhyay, and S. Gordon, Scavenger receptors in innate immunity. Curr Opin Immunol, 2002. 14(1): p. 123–8.
PubMed
CAS
Google Scholar
Basu, S., et al., CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin. Immunity, 2001. 14(3): p. 303–13.
PubMed
CAS
Google Scholar
Delneste, Y., et al., Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation. Immunity, 2002. 17(3): p. 353–62.
PubMed
CAS
Google Scholar
Guermonprez, P., et al., Antigen presentation and T cell stimulation by dendritic cells. Annu Rev Immunol, 2002. 20: p. 621–67.
PubMed
CAS
Google Scholar
Chow, A., et al., Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane. Nature, 2002. 418(6901): p. 988–94.
PubMed
CAS
Google Scholar
Guermonprez, P., et al., ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells. Nature, 2003. 425(6956): p. 397–402.
PubMed
CAS
Google Scholar
Fonteneau, J.F., M. Larsson, and N. Bhardwaj, Interactions between dead cells and dendritic cells in the induction of antiviral CTL responses. Curr Opin Immunol, 2002. 14(4): p. 471–7.
PubMed
CAS
Google Scholar
Ackerman, A.L., et al., Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens. Proc Natl Acad Sci U S A, 2003. 100(22): p. 12889–94.
PubMed
CAS
Google Scholar
Houde, M., et al., Phagosomes are competent organelles for antigen cross-presentation. Nature, 2003. 425(6956): p. 402–6.
PubMed
CAS
Google Scholar
Lizee, G., et al., Control of dendritic cell cross-presentation by the major histocompatibility complex class I cytoplasmic domain. Nat Immunol, 2003. 4(11): p. 1065–73.
PubMed
CAS
Google Scholar
Wolkers, M.C., et al., Antigen bias in T cell cross-priming. Science, 2004. 304(5675): p. 1314–7.
PubMed
CAS
Google Scholar
Moody, D.B. and S.A. Porcelli, Intracellular pathways of CD1 antigen presentation. Nat Rev Immunol, 2003. 3(1): p. 11–22.
PubMed
CAS
Google Scholar
Joyce, S. and L. Van Kaer, CD1-restricted antigen presentation: an oily matter. Curr Opin Immunol, 2003. 15(1): p. 95–104.
PubMed
CAS
Google Scholar
Fujii, S., et al., Prolonged IFN-gamma-producing NKT response induced with alpha-galactosylceramide-loaded DCs. Nat Immunol, 2002. 3(9): p. 867–74.
PubMed
CAS
Google Scholar
Fujimoto, Y., et al., CD83 expression influences CD4+ T cell development in the thymus. Cell, 2002. 108(6): p. 755–67.
PubMed
CAS
Google Scholar
Lechmann, M., et al., CD83 on dendritic cells: more than just a marker for maturation. Trends Immunol, 2002. 23(6): p. 273–5.
PubMed
CAS
Google Scholar
Matzinger, P., The danger model: a renewed sense of self. Science, 2002. 296(5566): p. 301–5.
PubMed
CAS
Google Scholar
Skoberne, M., A.S. Beignon, and N. Bhardwaj, Danger signals: a time and space continuum. Trends Mol Med, 2004. 10(6): p. 251–7.
PubMed
CAS
Google Scholar
Cheng, F., et al., A critical role for Stat3 signaling in immune tolerance. Immunity, 2003. 19(3): p. 425–36.
PubMed
CAS
Google Scholar
Kadowaki, N., et al., Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med, 2001. 194(6): p. 863–9.
PubMed
CAS
Google Scholar
Hornung, V., et al., Quantitative expression of toll-like receptor 1–10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol, 2002. 168(9): p. 4531–7.
PubMed
CAS
Google Scholar
Jarrossay, D., et al., Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells. Eur J Immunol, 2001. 31(11): p. 3388–93.
PubMed
CAS
Google Scholar
Delamarre, L., et al., Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate. Science, 2005. 307(5715): p. 1630–4.
PubMed
CAS
Google Scholar
Delamarre, L., H. Holcombe, and I. Mellman, Presentation of exogenous antigens on major histocompatibility complex (MHC) class I and MHC class II molecules is differentially regulated during dendritic cell maturation. J Exp Med, 2003. 198(1): p. 111–22.
PubMed
CAS
Google Scholar
Datta, S.K., et al., A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells. J Immunol, 2003. 170(8): p. 4102–10.
PubMed
CAS
Google Scholar
Shin, T., et al., Cooperative B7–1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor. J Exp Med, 2003. 198(1): p. 31–8.
PubMed
CAS
Google Scholar
Nguyen, L.T., et al., Cross-linking the B7 family molecule B7-DC directly activates immune functions of dendritic cells. J Exp Med, 2002. 196(10): p. 1393–8.
PubMed
CAS
Google Scholar
Suh, W.K., et al., The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. Nat Immunol, 2003. 4(9): p. 899–906.
PubMed
CAS
Google Scholar
Zang, X., et al., B7x: a widely expressed B7 family member that inhibits T cell activation. Proc Natl Acad Sci U S A, 2003. 100(18): p. 10388–92.
PubMed
CAS
Google Scholar
Colonna, M., TREMs in the immune system and beyond. Nat Rev Immunol, 2003. 3(6): p. 445–53.
PubMed
CAS
Google Scholar
Kolb-Maurer, A., et al., Production of IL-12 and IL-18 in human dendritic cells upon infection by Listeria monocytogenes. FEMS Immunol Med Microbiol, 2003. 35(3): p. 255–62.
PubMed
CAS
Google Scholar
Dzionek, A., et al., BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction. J Exp Med, 2001. 194(12): p. 1823–34.
PubMed
CAS
Google Scholar
Randolph, G.J., G. Sanchez-Schmitz, and V. Angeli, Factors and signals that govern the migration of dendritic cells via lymphatics: recent advances. Springer Semin Immunopathol, 2004.
Google Scholar
Ohl, L., et al., CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity, 2004. 21(2): p. 279–88.
PubMed
CAS
Google Scholar
Steinman, R.M. and M.C. Nussenzweig, Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci U S A, 2002. 99(1): p. 351–8.
PubMed
CAS
Google Scholar
Dhodapkar, M.V., et al., Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med, 2001. 193(2): p. 233–8.
PubMed
CAS
Google Scholar
Banchereau, J., et al., Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine. Cancer Res, 2001. 61(17): p. 6451–8.
PubMed
CAS
Google Scholar
Adams, S., D. O’Neill, and N. Bhardwaj, Maturation matters: importance of maturation for antitumor immunity of dendritic cell vaccines. J Clin Oncol, 2004. 22(18): p. 3834–5; author reply 3835.
PubMed
Google Scholar
Mossman, K.D., et al., Altered TCR signaling from geometrically repatterned immunological synapses. Science, 2005. 310(5751): p. 1191–3.
PubMed
CAS
Google Scholar
Stoll, S., et al., Dynamic imaging of T cell-dendritic cell interactions in lymph nodes. Science, 2002. 296(5574): p. 1873–6.
PubMed
Google Scholar
Bousso, P. and E. Robey, Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes. Nat Immunol, 2003. 4(6): p. 579–85.
PubMed
CAS
Google Scholar
Gett, A.V., et al., T cell fitness determined by signal strength. Nat Immunol, 2003. 4(4): p. 355–60.
PubMed
CAS
Google Scholar
van Stipdonk, M.J., et al., Dynamic programming of CD8+ T lymphocyte responses. Nat Immunol, 2003. 4(4): p. 361–5.
PubMed
Google Scholar
Tato, C.M., A. Laurence, and J.J. O’Shea, Helper T cell differentiation enters a new era: le roi est mort; vive le roi! J Exp Med, 2006. 203(4): p. 809–12.
PubMed
CAS
Google Scholar
Akbari, O., R.H. DeKruyff, and D.T. Umetsu, Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immunol, 2001. 2(8): p. 725–31.
PubMed
CAS
Google Scholar
Mora, J.R., et al., Selective imprinting of gut-homing T cells by Peyer’s patch dendritic cells. Nature, 2003. 424(6944): p. 88–93.
PubMed
CAS
Google Scholar
Hoebe, K., et al., Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature, 2003. 424(6950): p. 743–8.
PubMed
CAS
Google Scholar
Weiner, H.L., The mucosal milieu creates tolerogenic dendritic cells and T(R)1 and T(H)3 regulatory cells. Nat Immunol, 2001. 2(8): p. 671–2.
PubMed
CAS
Google Scholar
Shedlock, D.J. and H. Shen, Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science, 2003. 300(5617): p. 337–9.
PubMed
CAS
Google Scholar
Karsunky, H., et al., Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo. J Exp Med, 2003. 198(2): p. 305–13.
PubMed
CAS
Google Scholar
Schoenberger, S.P., et al., T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature, 1998. 393(6684): p. 480–3.
PubMed
CAS
Google Scholar
Croft, M., Co-stimulatory members of the TNFR family: keys to effective T-cell immunity? Nat Rev Immunol, 2003. 3(8): p. 609–20.
PubMed
CAS
Google Scholar
Rogers, P.R., et al., OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity, 2001. 15(3): p. 445–55.
PubMed
CAS
Google Scholar
Janssen, E.M., et al., CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death. Nature, 2005. 434(7029): p. 88–93.
PubMed
CAS
Google Scholar
Thurner, B., et al., Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application. J Immunol Methods, 1999. 223(1): p. 1–15.
PubMed
CAS
Google Scholar
O’Neill, D. and N. Bhardwaj, Generation of autologous peptide- and protein-pulsed dendritic cells for patient-specific immunotherapy. Methods Mol Med, 2005. 109: p. 97–112.
PubMed
CAS
Google Scholar
Hsu, F.J., et al., Vaccination of patients with B-cell lymphoma using autologous antigen- pulsed dendritic cells. Nat Med, 1996. 2(1): p. 52–8.
PubMed
CAS
Google Scholar
Kiertscher, S.M., et al., Granulocyte/macrophage-colony stimulating factor and interleukin-4 expand and activate type-1 dendritic cells (DC1) when administered in vivo to cancer patients. Int J Cancer, 2003. 107(2): p. 256–61.
PubMed
CAS
Google Scholar
Slingluff, C., et al., Clinical and Immunologic Results of a Randomized Phase II Trial of Vaccination Using Four Melanoma Peptides Either Administered in Granulocyte-Macrophage Colony-Stimulating Factor in Adjuvant or Pulsed on Dendritic Cells. J. Clin. Oncol., 2003(November): p. 4016–4026.
Google Scholar
Jonuleit, H., et al., A comparison of two types of dendritic cell as adjuvants for the induction of melanoma-specific T-cell responses in humans following intranodal injection. Int J Cancer, 2001. 93(2): p. 243–51.
PubMed
CAS
Google Scholar
Jonuleit, H., et al., Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur J Immunol, 1997. 27(12): p. 3135–42.
PubMed
CAS
Google Scholar
Sato, E., et al., Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci U S A, 2005. 102(51): p. 18538–43.
PubMed
CAS
Google Scholar
Dave, S.S., et al., Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. N Engl J Med, 2004. 351(21): p. 2159–69.
PubMed
CAS
Google Scholar
Hanada, K., J.W. Yewdell, and J.C. Yang, Immune recognition of a human renal cancer antigen through post-translational protein splicing. Nature, 2004. 427(6971): p. 252–6.
PubMed
CAS
Google Scholar
Vigneron, N., et al., An antigenic peptide produced by peptide splicing in the proteasome. Science, 2004. 304(5670): p. 587–90.
PubMed
CAS
Google Scholar
Warren, E.H., et al., An antigen produced by splicing of noncontiguous peptides in the reverse order. Science, 2006. 313(5792): p. 1444–7.
PubMed
CAS
Google Scholar
Simpson, A.J., et al., Cancer/testis antigens, gametogenesis and cancer. Nat Rev Cancer, 2005. 5(8): p. 615–25.
PubMed
CAS
Google Scholar
Schuler-Thurner, B., et al., Rapid induction of tumor-specific type 1 T helper cells in metastatic melanoma patients by vaccination with mature, cryopreserved, peptide- loaded monocyte-derived dendritic cells. J Exp Med, 2002. 195(10): p. 1279–88.
PubMed
CAS
Google Scholar
Nestle, F.O., et al., Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nat Med, 1998. 4(3): p. 328–32.
PubMed
CAS
Google Scholar
Dhodapkar, M.V., et al., Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells. J Clin Invest, 1999. 104(2): p. 173–80.
PubMed
CAS
Google Scholar
Fong, L., et al., Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy. Proc Natl Acad Sci U S A, 2001. 98(15): p. 8809–14.
PubMed
CAS
Google Scholar
Wang, R.F. and H.Y. Wang, Enhancement of antitumor immunity by prolonging antigen presentation on dendritic cells. Nat Biotechnol, 2002. 20(2): p. 149–54.
PubMed
CAS
Google Scholar
Berzofsky, J.A., J.D. Ahlers, and I.M. Belyakov, Strategies for designing and optimizing new generation vaccines. Nat Rev Immunol, 2001. 1(3): p. 209–19.
PubMed
CAS
Google Scholar
Timmerman, J.M., et al., Idiotype-pulsed dendritic cell vaccination for B-cell lymphoma: clinical and immune responses in 35 patients. Blood, 2002. 99(5): p. 1517–26.
PubMed
CAS
Google Scholar
Heiser, A., et al., Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors. J Clin Invest, 2002. 109(3): p. 409–17.
PubMed
CAS
Google Scholar
Engelmayer, J., et al., Mature dendritic cells infected with canarypox virus elicit strong anti- human immunodeficiency virus CD8+ and CD4+ T-cell responses from chronically infected individuals. J Virol, 2001. 75(5): p. 2142–53.
PubMed
CAS
Google Scholar
Dietz, A.B. and S. Vuk-Pavlovic, High efficiency adenovirus-mediated gene transfer to human dendritic cells. Blood, 1998. 91(2): p. 392–8.
PubMed
CAS
Google Scholar
Su, Z., et al., Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cells. Cancer Res, 2003. 63(9): p. 2127–33.
PubMed
CAS
Google Scholar
Thumann, P., et al., Antigen loading of dendritic cells with whole tumor cell preparations. J Immunol Methods, 2003. 277(1–2): p. 1–16.
PubMed
CAS
Google Scholar
Parkhurst, M.R., et al., Hybrids of dendritic cells and tumor cells generated by electrofusion simultaneously present immunodominant epitopes from multiple human tumor-associated antigens in the context of MHC class I and class II molecules. J Immunol, 2003. 170(10): p. 5317–25.
PubMed
CAS
Google Scholar
Morse, M.A., et al., Migration of human dendritic cells after injection in patients with metastatic malignancies. Cancer Res, 1999. 59(1): p. 56–8.
PubMed
CAS
Google Scholar
Mackensen, A., et al., Homing of intravenously and intralymphatically injected human dendritic cells generated in vitro from CD34+ hematopoietic progenitor cells. Cancer Immunol Immunother, 1999. 48(2–3): p. 118–22.
PubMed
CAS
Google Scholar
Mullins, D.W., et al., Route of Immunization with Peptide-pulsed Dendritic Cells Controls the Distribution of Memory and Effector T Cells in Lymphoid Tissues and Determines the Pattern of Regional Tumor Control. J Exp Med, 2003. 198(7): p. 1023–34.
PubMed
CAS
Google Scholar
Fong, L., et al., Dendritic cells injected via different routes induce immunity in cancer patients. J Immunol, 2001. 166(6): p. 4254–9.
PubMed
CAS
Google Scholar
Ridolfi, R., et al., Evaluation of in vivo labelled dendritic cell migration in cancer patients. J Transl Med, 2004. 2(1): p. 27.
PubMed
Google Scholar
Nair, S., et al., Injection of immature dendritic cells into adjuvant-treated skin obviates the need for ex vivo maturation. J Immunol, 2003. 171(11): p. 6275–82.
PubMed
CAS
Google Scholar
Suzuki, H., et al., Imiquimod, a topical immune response modifier, induces migration of Langerhans cells. J Invest Dermatol, 2000. 114(1): p. 135–41.
PubMed
CAS
Google Scholar
Badovinac, V.P., et al., Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination. Nat Med, 2005. 11(7): p. 748–56.
PubMed
CAS
Google Scholar
Ridgway, D., The first 1000 dendritic cell vaccinees. Cancer Invest, 2003. 21(6): p. 873–86.
PubMed
Google Scholar
Therasse, P., et al., New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst, 2000. 92(3): p. 205–16.
PubMed
CAS
Google Scholar
Schadendorf, D., et al., Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: a randomized phase III trial of the DC study group of the DeCOG. Ann Oncol, 2006. 17(4): p. 563–70.
PubMed
CAS
Google Scholar
Holtl, L., et al., Immunotherapy of metastatic renal cell carcinoma with tumor lysate-pulsed autologous dendritic cells. Clin Cancer Res, 2002. 8(11): p. 3369–76.
PubMed
CAS
Google Scholar
O’Rourke, M.G., et al., Durable complete clinical responses in a phase I/II trial using an autologous melanoma cell/dendritic cell vaccine. Cancer Immunol Immunother, 2003. 52(6): p. 387–95.
PubMed
Google Scholar
Maier, T., et al., Vaccination of patients with cutaneous T-cell lymphoma using intranodal injection of autologous tumor-lysate-pulsed dendritic cells. Blood, 2003. 102(7): p. 2338–44.
PubMed
CAS
Google Scholar
Antonia, S.J., et al., Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancer. Clin Cancer Res, 2006. 12(3 Pt 1): p. 878–87.
PubMed
CAS
Google Scholar
Arnould, L., et al., Trastuzumab-based treatment of HER2-positive breast cancer: an antibody-dependent cellular cytotoxicity mechanism? Br J Cancer, 2006. 94(2): p. 259–67.
PubMed
CAS
Google Scholar
Babatz, J., et al., Induction of cellular immune responses against carcinoembryonic antigen in patients with metastatic tumors after vaccination with altered peptide ligand-loaded dendritic cells. Cancer Immunol Immunother, 2006. 55(3): p. 268–76.
PubMed
CAS
Google Scholar
Di Pucchio, T., et al., Immunization of stage IV melanoma patients with Melan-A/MART-1 and gp100 peptides plus IFN-alpha results in the activation of specific CD8(+) T cells and monocyte/dendritic cell precursors. Cancer Res, 2006. 66(9): p. 4943–51.
PubMed
Google Scholar
Fuessel, S., et al., Vaccination of hormone-refractory prostate cancer patients with peptide cocktail-loaded dendritic cells: results of a phase I clinical trial. Prostate, 2006. 66(8): p. 811–21.
PubMed
CAS
Google Scholar
Lou, E., et al., A phase II study of active immunotherapy with PANVAC or autologous, cultured dendritic cells infected with PANVAC after complete resection of hepatic metastases of colorectal carcinoma. Clin Colorectal Cancer, 2006. 5(5): p. 368–71.
PubMed
Google Scholar
Loveland, B.E., et al., Mannan-MUC1-pulsed dendritic cell immunotherapy: a phase I trial in patients with adenocarcinoma. Clin Cancer Res, 2006. 12(3 Pt 1): p. 869–77.
PubMed
CAS
Google Scholar
Perambakam, S., et al., Induction of specific T cell immunity in patients with prostate cancer by vaccination with PSA146–154 peptide. Cancer Immunol Immunother, 2006. 55(9): p. 1033–42.
PubMed
CAS
Google Scholar
Thomas-Kaskel, A.K., et al., Vaccination of advanced prostate cancer patients with PSCA and PSA peptide-loaded dendritic cells induces DTH responses that correlate with superior overall survival. Int J Cancer, 2006.
Google Scholar
Trakatelli, M., et al., A new dendritic cell vaccine generated with interleukin-3 and interferon-beta induces CD8+ T cell responses against NA17-A2 tumor peptide in melanoma patients. Cancer Immunol Immunother, 2006. 55(4): p. 469–74.
PubMed
CAS
Google Scholar
Tuettenberg, A., et al., Induction of strong and persistent MelanA/MART-1-specific immune responses by adjuvant dendritic cell-based vaccination of stage II melanoma patients. Int J Cancer, 2006. 118(10): p. 2617–27.
PubMed
CAS
Google Scholar
Wierecky, J., M. Mueller, and P. Brossart, Dendritic cell-based cancer immunotherapy targeting MUC-1. Cancer Immunol Immunother, 2006. 55(1): p. 63–7.
PubMed
CAS
Google Scholar
Osada, T., et al., NK cell activation by dendritic cell vaccine: a mechanism of action for clinical activity. Cancer Immunol Immunother, 2006. 55(9): p. 1122–31.
PubMed
Google Scholar
Wilson, N.S., et al., Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity. Nat Immunol, 2006. 7(2): p. 165–72.
PubMed
CAS
Google Scholar
Dillon, S., et al., Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance. J Clin Invest, 2006. 116(4): p. 916–28.
PubMed
CAS
Google Scholar
Su, Z., et al., Enhanced induction of telomerase-specific CD4(+) T cells using dendritic cells transfected with RNA encoding a chimeric gene product. Cancer Res, 2002. 62(17): p. 5041–8.
PubMed
CAS
Google Scholar
Merad, M., et al., In vivo manipulation of dendritic cells to induce therapeutic immunity. Blood, 2002. 99(5): p. 1676–82.
PubMed
CAS
Google Scholar
Cho, H.J., et al., Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity by a T-helper cell-independent mechanism. Nat Biotechnol, 2000. 18(5): p. 509–14.
PubMed
CAS
Google Scholar
Schneeberger, A., et al., CpG motifs are efficient adjuvants for DNA cancer vaccines. J Invest Dermatol, 2004. 123(2): p. 371–9.
PubMed
CAS
Google Scholar
Weeratna, R.D., et al., TLR agonists as vaccine adjuvants: comparison of CpG ODN and Resiquimod (R-848). Vaccine, 2005. 23(45): p. 5263–70.
PubMed
CAS
Google Scholar
Wille-Reece, U., et al., Immunization with HIV-1 Gag protein conjugated to a TLR7/8 agonist results in the generation of HIV-1 Gag-specific Th1 and CD8+ T cell responses. J Immunol, 2005. 174(12): p. 7676–83.
PubMed
CAS
Google Scholar
Itoh, T. and E. Celis, Transcutaneous immunization with cytotoxic T-cell peptide epitopes provides effective antitumor immunity in mice. J Immunother, 2005. 28(5): p. 430–7.
PubMed
CAS
Google Scholar
Klinman, D.M., et al., Use of CpG oligodeoxynucleotides as immune adjuvants. Immunol Rev, 2004. 199: p. 201–16.
PubMed
CAS
Google Scholar
Speiser, D.E., et al., Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909. J Clin Invest, 2005. 115(3): p. 739–46.
PubMed
CAS
Google Scholar
Kim, T.W., et al., Enhancing DNA vaccine potency by combining a strategy to prolong dendritic cell life with intracellular targeting strategies. J Immunol, 2003. 171(6): p. 2970–6.
PubMed
CAS
Google Scholar
Sudowe, S., et al., Transcriptional targeting of dendritic cells in gene gun-mediated DNA immunization favors the induction of type 1 immune responses. Mol Ther, 2003. 8(4): p. 567–75.
PubMed
CAS
Google Scholar
Garg, S., et al., Genetic tagging shows increased frequency and longevity of antigen-presenting, skin-derived dendritic cells in vivo. Nat Immunol, 2003. 4(9): p. 907–12.
PubMed
CAS
Google Scholar
MartIn-Fontecha, A., et al., Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming. J Exp Med, 2003. 198(4): p. 615–21.
PubMed
CAS
Google Scholar
Belli, F., et al., Vaccination of metastatic melanoma patients with autologous tumor-derived heat shock protein gp96-peptide complexes: clinical and immunologic findings. J Clin Oncol, 2002. 20(20): p. 4169–80.
PubMed
CAS
Google Scholar
Wang, H.Y., et al., Induction of CD4(+) T cell-dependent antitumor immunity by TAT-mediated tumor antigen delivery into dendritic cells. J Clin Invest, 2002. 109(11): p. 1463–70.
PubMed
CAS
Google Scholar
Mohty, M., et al., All-trans retinoic acid skews monocyte differentiation into interleukin-12-secreting dendritic-like cells. Br J Haematol, 2003. 122(5): p. 829–36.
PubMed
CAS
Google Scholar
Adams, S., et al., PT-100, a small molecule dipeptidyl peptidase inhibitor, has potent antitumor effects and augments antibody-mediated cytotoxicity via a novel immune mechanism. Cancer Res, 2004. 64(15): p. 5471–80.
PubMed
CAS
Google Scholar
Nefedova, Y., et al., Hyperactivation of STAT3 is involved in abnormal differentiation of dendritic cells in cancer. J Immunol, 2004. 172(1): p. 464–74.
PubMed
CAS
Google Scholar
Song, X.T., et al., An alternative and effective HIV vaccination approach based on inhibition of antigen presentation attenuators in dendritic cells. PLoS Med, 2006. 3(1): p. e11.
PubMed
Google Scholar
Nair, S., et al., Synergy between tumor immunotherapy and antiangiogenic therapy. Blood, 2003. 102(3): p. 964–71.
PubMed
CAS
Google Scholar
Gabrilovich, D.I., et al., Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function. Clin Cancer Res, 1999. 5(10): p. 2963–70.
PubMed
CAS
Google Scholar
Rini, B.I., et al., Combination immunotherapy with prostatic acid phosphatase pulsed antigen-presenting cells (provenge) plus bevacizumab in patients with serologic progression of prostate cancer after definitive local therapy. Cancer, 2006. 107(1): p. 67–74.
PubMed
CAS
Google Scholar
Borg, C., et al., Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects. J Clin Invest, 2004. 114(3): p. 379–88.
PubMed
CAS
Google Scholar
Ghiringhelli, F., et al., CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner. J Exp Med, 2005. 202(8): p. 1075–85.
PubMed
CAS
Google Scholar
Hodi, F.S., et al., Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients. Proc Natl Acad Sci U S A, 2003. 100(8): p. 4712–7.
PubMed
CAS
Google Scholar
Phan, G.Q., et al., Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci U S A, 2003. 100(14): p. 8372–7.
PubMed
CAS
Google Scholar
Attia, P., et al., Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4. J Clin Oncol, 2005. 23(25): p. 6043–53.
PubMed
CAS
Google Scholar
Beck, K.E., et al., Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4. J Clin Oncol, 2006. 24(15): p. 2283–9.
PubMed
CAS
Google Scholar
Curiel, T.J., et al., Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat Med, 2003. 9(5): p. 562–7.
PubMed
CAS
Google Scholar
Watanabe, N., et al., BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol, 2003. 4(7): p. 670–9.
PubMed
CAS
Google Scholar
Carreno, B.M. and M. Collins, BTLA: a new inhibitory receptor with a B7-like ligand. Trends Immunol, 2003. 24(10): p. 524–7.
PubMed
CAS
Google Scholar
Francois Bach, J., Regulatory T cells under scrutiny. Nat Rev Immunol, 2003. 3(3): p. 189–98.
PubMed
CAS
Google Scholar
Jonuleit, H. and E. Schmitt, The regulatory T cell family: distinct subsets and their interrelations. J Immunol, 2003. 171(12): p. 6323–7.
PubMed
CAS
Google Scholar
Woo, E.Y., et al., Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer. Cancer Res, 2001. 61(12): p. 4766–72.
PubMed
CAS
Google Scholar
Wolf, A.M., et al., Increase of regulatory T cells in the peripheral blood of cancer patients. Clin Cancer Res, 2003. 9(2): p. 606–12.
PubMed
Google Scholar
Curiel, T.J., et al., Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med, 2004. 10(9): p. 942–9.
PubMed
CAS
Google Scholar
Oldenhove, G., et al., CD4+ CD25+ regulatory T cells control T helper cell type 1 responses to foreign antigens induced by mature dendritic cells in vivo. J Exp Med, 2003. 198(2): p. 259–66.
PubMed
CAS
Google Scholar
Dannull, J., et al., Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells. J Clin Invest, 2005. 115(12): p. 3623–33.
PubMed
CAS
Google Scholar
Asavaroengchai, W., Y. Kotera, and J.J. Mule, Tumor lysate-pulsed dendritic cells can elicit an effective antitumor immune response during early lymphoid recovery. Proc Natl Acad Sci U S A, 2002. 99(2): p. 931–6.
PubMed
CAS
Google Scholar
Rapoport, A.P., et al., Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer. Nat Med, 2005.
Google Scholar
Dudley, M.E., et al., Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma. J Clin Oncol, 2005. 23(10): p. 2346–57.
PubMed
CAS
Google Scholar
Gattinoni, L., et al., Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells. J Exp Med, 2005. 202(7): p. 907–12.
PubMed
CAS
Google Scholar
Morgan, R.A., et al., Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes. Science, 2006.
Google Scholar
Overwijk, W.W., et al., Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells. J Exp Med, 2003. 198(4): p. 569–80.
PubMed
CAS
Google Scholar
Friedman, E.J., Immune modulation by ionizing radiation and its implications for cancer immunotherapy. Curr Pharm Des, 2002. 8(19): p. 1765–80.
PubMed
CAS
Google Scholar
Chen, Z., et al., Combined radiation therapy and dendritic cell vaccine for treating solid tumors with liver micro-metastasis. J Gene Med, 2005. 7(4): p. 506–17.
PubMed
CAS
Google Scholar
Chi, K.H., et al., Combination of conformal radiotherapy and intratumoral injection of adoptive dendritic cell immunotherapy in refractory hepatoma. J Immunother, 2005. 28(2): p. 129–35.
PubMed
Google Scholar
Lake, R.A. and B.W. Robinson, Immunotherapy and chemotherapy–a practical partnership. Nat Rev Cancer, 2005. 5(5): p. 397–405.
PubMed
CAS
Google Scholar
Gabrilovich, D.I., et al., Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat Med, 1996. 2(10): p. 1096–103.
PubMed
CAS
Google Scholar
Gabrilovich, D.I., et al., Decreased antigen presentation by dendritic cells in patients with breast cancer. Clin Cancer Res, 1997. 3(3): p. 483–90.
PubMed
CAS
Google Scholar
Furumoto, K., et al., Induction of potent antitumor immunity by in situ targeting of intratumoral DCs. J Clin Invest, 2004. 113(5): p. 774–83.
PubMed
CAS
Google Scholar
Sharma, S., et al., Cytokines and chemokines are expressed at different levels in small and large murine colon-26 tumors following intratumoral injections of CpG ODN. Neoplasia, 2004. 6(5): p. 523–8.
PubMed
CAS
Google Scholar
Carpentier, A.F., et al., Successful treatment of intracranial gliomas in rat by oligodeoxynucleotides containing CpG motifs. Clin Cancer Res, 2000. 6(6): p. 2469–73.
PubMed
CAS
Google Scholar
Meng, Y., et al., Successful combination of local CpG-ODN and radiotherapy in malignant glioma. Int J Cancer, 2005. 116(6): p. 992–7.
PubMed
CAS
Google Scholar