Embryonal tumors 25%
Teratocarcinomata 25%, teratomata 5%
Male germ cell tumors result from the transformation of premeiotic or early meiotic germ cells and exhibit embryonal like differentiation of the three germinal layers. They are the most common malignant neoplasms of males aged 15-35 years and a major cause of cancer-induced deaths in this age group. In females, germ cell tumors account for 30% of all ovarian tumors, but only 1–3% of ovarian cancers in North America. In younger women, germ cell lesions are more common, accounting for 60% of ovarian tumors arising under the age of 21. Worldwide, the highest incidence for germ cell tumors is in Scandinavia.
Germ cell tumors may develop extragonadally. Mediastinal germ cell tumors are rare growths that predominantly affect young males. They may represent isolated metastases from inapparent gonadal primary sites, potentially as a consequence of the abnormal migration of germ cells during embryogenesis.
KeywordsGerm Cell Germ Cell Tumor Tuberous Sclerosis Complex Turner Syndrome Embryonic Tumor
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