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Tight junctions and metastasis of breast cancer

  • Chapter
Metastasis of Breast Cancer

Part of the book series: Cancer Metastasis – Biology and Treatment ((CMBT,volume 11))

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Abstract

TJs are the apical most structure between epithelial and endothelial cells. Although well known as functioning as a control for paracellular diffusion of ions and certain molecules, it has recently become apparent that the TJ has a vital role in maintaining cell integrity and that loss of cohesion of the TJ structure can lead to invasion and thus metastasis of breast cancer cells.

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Authors and Affiliations

  1. Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, CF14 4XN, Heath Park, Cardiff, UK

    Tracey A. Martin PhD

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  1. Tracey A. Martin PhD
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Editors and Affiliations

  1. Department of Surgery, Cardiff University School of Medicine, Heath Park, CF14 4XN, Cardiff, UK

    Robert E. Mansel MS, FRCS, CBE

  2. Michell Cancer Institute, University of South Alabama, 307 N. University Blvd., 2015, 36688, AL, USA

    Oystein Fodstad PhD

  3. Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, CF14 4XN, Heath Park, Cardiff, UK

    Wen G. Jiang MB, BCh, MD

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Martin, T.A. (2007). Tight junctions and metastasis of breast cancer. In: Mansel, R.E., Fodstad, O., Jiang, W.G. (eds) Metastasis of Breast Cancer. Cancer Metastasis – Biology and Treatment, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5867-7_5

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