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Orthotopic Metastatic Mouse Models of Prostate Cancer

  • Robert M. Hoffman
Part of the Cancer Metastasis – Biology and Treatment book series (CMBT, volume 10)

Abstract

Orthotopic metastatic models of prostate cancer are reviewed here. Emphasis is placed on surgical orthotopic implantation models in nude mice. The advantages of surgical orthotopic implantation of tissue fragments are discussed with regard to resulting metastasis which reflect the clinical pattern of prostate cancer. The use of green Cancer statistics, luorescent protein and red fluorescent protein to image primary tumor growth and metastasis, including whole-body imaging of prostate cancer, is discussed. The application of the models for gene expression studies, drug discovery, and gene therapy is also reviewed.

Key words

prostate cancer cell lines surgical orthotopic implantation green fluorescent protein red fluorescent protein whole-body imaging metastasis drug discovery 

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© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Robert M. Hoffman
    • 1
  1. 1.Department of SurgeryUCSD Medical CenterSan DiegoUSA

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