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A Data-Driven, Flexible Machine Learning Strategy for the Classification of Biomedical Data

  • Rajmund L. Somorjai
  • Murray E. Alexander
  • Richard Baumgartner
  • Stephanie Booth
  • Christopher Bowman
  • Aleksander Demko
  • Brion Dolenko
  • Marina Mandelzweig
  • Aleksander E. Nikulin
  • Nicolino J. Pizzi
  • Erinija Pranckeviciene
  • Arthur R. Summers
  • Peter Zhilkin
Part of the Computational Biology book series (COBO, volume 5)

While biomedical data acquired from the latest spectroscopic modalities yield important information relevant to many diagnostic or prognostic procedures, they also present significant challenges for analysis, classification and interpretation. These challenges include sample sparsity, high-dimensional feature spaces, and noise/artifact signatures. Since a dataindependent ‘universal’ classifier does not exist, a classification strategy is needed, possessing five key components acting in concert: data visualization, preprocessing, feature space dimensionality reduction, reliable/robust classifier development, and classifier aggregation/fusion. These components, which should be flexible, data-driven, extensible, and computationally efficient, must provide accurate, reliable diagnosis/prognosis with the fewest maximally discriminatory, yet medically interpretable, features.

Keywords

Feature Selection Feature Space Linear Discriminant Analysis Feature Selection Method Biomedical Data 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2004

Authors and Affiliations

  • Rajmund L. Somorjai
    • 1
  • Murray E. Alexander
    • 1
  • Richard Baumgartner
    • 1
  • Stephanie Booth
    • 2
  • Christopher Bowman
    • 1
  • Aleksander Demko
    • 1
  • Brion Dolenko
    • 1
  • Marina Mandelzweig
    • 1
  • Aleksander E. Nikulin
    • 1
  • Nicolino J. Pizzi
    • 1
  • Erinija Pranckeviciene
    • 1
  • Arthur R. Summers
    • 1
  • Peter Zhilkin
    • 1
  1. 1.Biomedical Informatics Group, Institute for BiodiagnosticsNational Research Council CanadaWinnipegCanada
  2. 2.National Microbiology LaboratoryWinnipegCanada

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