Systems Level Modeling of Gene Regulatory Networks

The perhaps most important signaling network in living cells is constituted by the interactions of proteins with the genome—the gene regulatory network of the cell. From a system level point of view, the various interactions and control loops, which form a genetic network, represent the basis upon which the vast complexity and flexibility of life processes emerges. Here we review ways by which artificial intelligence approaches can help gaining a more quantitative understanding of regulatory genetic networks at the systems level.