Abstract
A science-based regulatory system is expected to have three key elements in requirements for enhanced biocontrol agents: no off-site dispersal, poor long-term environmental persistence, and limited possibility of recombination with other pathogens. These can be achieved by using appropriate combinations of some of the following elements: synergists that are present for a single generation; organisms that are permanently asporogenic; and by inserting genes in tandem with virulence-enhancing genes that would render recombined offspring to be unfit to compete in the environment.
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Gressel, J. (2007). FAILSAFE MECHANISMS FOR PREVENTING GENE FLOW AND ORGANISM DISPERSAL OF ENHANCED MICROBIAL BIOCONTROL AGENTS. In: Vurro, M., Gressel, J. (eds) Novel Biotechnologies for Biocontrol Agent Enhancement and Management. NATO Security through Science Series. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5799-1_19
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DOI: https://doi.org/10.1007/978-1-4020-5799-1_19
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