Force Unfolding Single RNAs: From Equilibrium to Far-From Equilibrium

  • Fei Liu
  • Huan Tong
  • Zhong-Can Ou-Yang
Part of the Solid Mechanics and its Applications book series (SMIA, volume 144)


We summarize our recent simulation progress of micromanipulation experiments on RNAs. We mainly consults with two important small RNAs unfolding experiments carried out by Bustamante group. Our results show that, in contrast to protein cases, using the single polymer elastic theory and the well-known RNA secondary structure free energy knowledge, we can successively simulate various behaviors of force unfolding RNAs under different experimental setups from equilibrium to far-from equilibrium.

Key words

continuous time Monte Carlo method Jarzynski’s equality RNA single-molecule manipulation 


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Copyright information

© Springer 2007

Authors and Affiliations

  • Fei Liu
    • 1
  • Huan Tong
    • 1
  • Zhong-Can Ou-Yang
    • 1
    • 2
  1. 1.Center for Advanced StudyTsinghua UniversityBeijingChina
  2. 2.Institute of Theoretical PhysicsThe Chinese Academy of SciencesBeijingChina

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