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HSP60: A Pleiotropic Immune Signal

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Heat Shock Proteins: Potent Mediators of Inflammation and Immunity

Part of the book series: Heat Shock Proteins ((HESP,volume 1))

Abstract

Heat shock protein (HSP) 60 functions as a key signal to the immune system: its expression is up-regulated under inflammation and HSP60-reactive T and B cells were observed in almost all inflammatory diseases. Moreover, HSP60 induces pro-inflammatory phenotype in innate immune cells via Toll-like receptors (TLRs). Accordingly, HSP60 has been considered a pro-inflammatory “danger signal”. However, HSP60 have immunoregulatory potential and could arrest inflammatory damage. In this chapter we discuss recent findings indicating that T and B cells may directly respond to HSP60 via TLR-2 and TLR4 respectively. HSP60 inhibits T-cell chemotaxis, shift the cytokine secretion balance towards a Th2 phenotype, and activates the suppression ability of Treg. B cells responding to HSP60 secreted also high levels of IL-10. Then, these innate effects of HSP60 on adaptive immune system lead to resolution of inflammation. Thus, HSP60, which is up-regulated by stress and inflammation, can innately resolve it

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Authors and Affiliations

  1. The Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel

    Alexandra Zanin-Zhorov & Irun R. Cohen

Authors
  1. Alexandra Zanin-Zhorov
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  2. Irun R. Cohen
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Editors and Affiliations

  1. Effie and Wofford Cain Centennial Endowed Chair in Clinical Pathology, Chief, Division of Investigative Pathology Scott & White Memorial Hospital and Clinic and The Texas A&M University System Health Science Center College of Medicine Temple, TX, U.S.A

    Alexzander A. A. Asea

  2. Department of Surgery, School of Medicine, University of California, San Diego, CA, U.S.A

    Antonio De Maio

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Zanin-Zhorov, A., Cohen, I.R. (2007). HSP60: A Pleiotropic Immune Signal. In: Asea, A.A., Maio, A.D. (eds) Heat Shock Proteins: Potent Mediators of Inflammation and Immunity. Heat Shock Proteins, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5585-0_16

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