The Role of Heat Shock Proteins in the Elicitation of Immune Responses

  • Charles A Gullo
  • Paul Macary
  • Michael Graner
Part of the Heat Shock Proteins book series (HESP, volume 1)

Abstract

Heat Shock Proteins (HSP), well known for their protein/polpypetide chaperone activities, display a remarkable ability to elicit peptide-based immune responses. The exact manner in which they do so, their physiological role in this process, and their distinct ability to promote adaptive immune response is the subject of this chapter. The first part of the chapter will deal with the general known antigenic stimulation properties of heat shock proteins, the second will deal with the separation of innate and adaptive immune responses as learned from studies with GP96, Hsp70, and Mycobacterium Hsp70 and finally the third will deal with the subject of chaperone rich cell lysates and means of isolating these HSP immunogenic complexes

Keywords

Adjuvanticity antigen simulation HSP MHC 

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Copyright information

© Springer 2007

Authors and Affiliations

  • Charles A Gullo
    • 1
  • Paul Macary
    • 2
  • Michael Graner
    • 3
  1. 1.Department of Clinical ResearchSingapore General HospitalSingapore
  2. 2.Immunology ProgramNational University of SingaporeSingapore
  3. 3.The Preston Robert Tisch Brain Tumor Center at Duke UniversityDuke University Medical SchoolUSA

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