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The Role of Heat Shock Proteins in the Elicitation of Immune Responses

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Heat Shock Proteins: Potent Mediators of Inflammation and Immunity

Part of the book series: Heat Shock Proteins ((HESP,volume 1))

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Abstract

Heat Shock Proteins (HSP), well known for their protein/polpypetide chaperone activities, display a remarkable ability to elicit peptide-based immune responses. The exact manner in which they do so, their physiological role in this process, and their distinct ability to promote adaptive immune response is the subject of this chapter. The first part of the chapter will deal with the general known antigenic stimulation properties of heat shock proteins, the second will deal with the separation of innate and adaptive immune responses as learned from studies with GP96, Hsp70, and Mycobacterium Hsp70 and finally the third will deal with the subject of chaperone rich cell lysates and means of isolating these HSP immunogenic complexes

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Authors and Affiliations

  1. Department of Clinical Research, Singapore General Hospital, Singapore

    Charles A Gullo

  2. Immunology Program, National University of Singapore, Singapore

    Paul Macary

  3. The Preston Robert Tisch Brain Tumor Center at Duke University, Duke University Medical School, USA

    Michael Graner

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  1. Charles A Gullo
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  2. Paul Macary
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Editors and Affiliations

  1. Effie and Wofford Cain Centennial Endowed Chair in Clinical Pathology, Chief, Division of Investigative Pathology Scott & White Memorial Hospital and Clinic and The Texas A&M University System Health Science Center College of Medicine Temple, TX, U.S.A

    Alexzander A. A. Asea

  2. Department of Surgery, School of Medicine, University of California, San Diego, CA, U.S.A

    Antonio De Maio

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Gullo, C.A., Macary, P., Graner, M. (2007). The Role of Heat Shock Proteins in the Elicitation of Immune Responses. In: Asea, A.A., Maio, A.D. (eds) Heat Shock Proteins: Potent Mediators of Inflammation and Immunity. Heat Shock Proteins, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5585-0_12

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