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Release of Heat Shock Proteins: Passive Versus Active Release Mechanisms

  • Alexzander A.A. Asea
Part of the Heat Shock Proteins book series (HESP, volume 1)

Abstract

There is now no doubt that heat shock proteins have a profound immunoregulatory effect on the host’s immune system. This knowledge has successfully been harnessed to generate a number of important clinical trails. However, one intriguing question that remains to be answered is how heat shock proteins (HSP) which do not have peptide leader sequence targeting secretion can gain access to the extracellular milieu. This chapter will discuss the most recent findings in the area of HSP release and attempts to broadly categorize these findings into two basic mechanisms; the passive and active mechanisms

Keywords

Chaperokine exosomes heat shock proteins inflammation lipid rafts protein transport stress 

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© Springer 2007

Authors and Affiliations

  • Alexzander A.A. Asea
    • 1
  1. 1.Division of Investigative PathologyScott & White Memorial Hospital and Clinic and The Texas A&M University System Health Science Center College of MedicineTempleUSA

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