The phenomenological models of Chapter 9 are not complete explanations of the voltage-dependent gating, selectivity and permeation processes they are intended to explain. The Hodgkin — Huxley and related models fail to explain microscopic phenomena, such as the depressed Cole—Cole semicircles and the observed fluctuations. In this chapter we examine proposed microscopic models that seek to build a theoretical scaffolding to answer the questions posed in Chapter 1.
Noise and admittance studies show that the Na channel is a nonlinear, nonequilibrium system. Neurotoxin studies show that the transition to single-channel sodium conduction is suppressed by a single TTX molecule. We will analyze the conventional view that the channel is a water-filled structural pore before considering alternative models more or less grounded on physical and chemical principles. Since speculation appears to be necessary for a leap to a new paradigm, we will review a number of proposed models, most but not all microscopic.
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(2009). Microscopic Models Of Channel Function. In: Leuchtag, H.R. (eds) Voltage-Sensitive Ion Channels. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5525-6_14
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