Abstract
Safety, yield and scalability represent critical issues in production of genemodified cells (GMC) for clinical applications. Currently open systems, based on culture flasks, are used for production of TK-transduced T cells. Such systems may be used, without significant risk of contamination, only if limited numbers of cells (up to 108-109) are required. Thus a method for cell manipulation and culturing in a closed system has been developed.
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© 2007 Springer
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Benati, C., Birolo, R.S., Catamancio, S.L., Radrizzani, M., Sendresen, C., Toma, S. (2007). T-Lymphocytes Transduced with SFCMM-3 Vector in a Closed System. In: Smith, R. (eds) Cell Technology for Cell Products., vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5476-1_39
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DOI: https://doi.org/10.1007/978-1-4020-5476-1_39
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-5475-4
Online ISBN: 978-1-4020-5476-1
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