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Purification of Rabies Virus Produced on Vero Cells Using Chromatography Techniques

  • Mohamed Chtioui
  • Khaled Trabelsi
  • Héla Kallel

Abstract

Rabies encephalomyelitis is a fatal disease. Fifty to seventy thousands death and 10 millions post-exposure treatment are reported yearly among humans. This infection remains a major public health concern, particularly in developing countries. Pre and post exposure vaccination remains the most efficient way to protect humans.

Keywords

Vero Cell Rabies Virus Recovery Yield Virus Suspension Chromatography Support 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Gaudin Y (2000) Rabies virus-induced membrane fusion pathway. J Cell Biol, 150, 601–612CrossRefGoogle Scholar
  2. Gaudin Y, Ruigrok RW, Knossow M and Flamand A (1993) Low-pH conformational changes of rabies virus glycoprotein and their role in membrane fusion. J. Virol, 67, 1365–1372Google Scholar
  3. Trabelsi K, Rourou S, Loukil H, Majoul S and Kallel H (2005) Comparison of various culture modes for the production of rabies virus by Vero cells grown on microcarriers in a 2-l bioreactor. Enzyme & Microbial Technology, 36, 514–519CrossRefGoogle Scholar

Copyright information

© Springer 2007

Authors and Affiliations

  • Mohamed Chtioui
    • 1
  • Khaled Trabelsi
    • 1
  • Héla Kallel
    • 1
  1. 1.Viral Vaccines Research & Development UnitInstitut Pasteur de Tunis. 13TunisTunisia

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