Boron and Prostate Cancer a Model for Understanding Boron Biology
The aim of this paper is describe how boron was identified as an anticancer agent for prostate cancer and how research using human prostate cells identified a biochemical mechanism that may explain many of the diverse effects reported for the element in plants and animals. At physiological pH, boric acid binds to NAD+, a coenzyme in metabolism and substrate for an enzyme in the NAD+ cADPR system of calcium signaling.
KeywordsProstate Cancer Boric Acid Prostate Cancer Cell Proliferation Human Prostate Cell Boron Supplementation
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- Hing A.W. and Devesa S.S., 2001 Trends and patterns of prostate cancer. What do they suggest? Epidem. Rev. 23, 3–13.Google Scholar
- Kim D.H., Faull K.F., Norris A.J., and Eckhert C.D. Submitted for publication.Google Scholar
- Nagata T., Iizumi S., Satoh K., Ooka H., Kawai J., Carninci P., Hayashizaki Y., Otoma Y., Murakami K., Matsubara K., and Kikuchi S., 2004 Comparative analysis of plant and animal calcium signal transduction element using plant full-length cDNA data. Mol. Biol. Evol. 21, 1855–1870.PubMedCrossRefGoogle Scholar