Boron and Prostate Cancer a Model for Understanding Boron Biology

  • Curtis Eckhert
  • Wade Barranco
  • Danny Kim

Abstract

The aim of this paper is describe how boron was identified as an anticancer agent for prostate cancer and how research using human prostate cells identified a biochemical mechanism that may explain many of the diverse effects reported for the element in plants and animals. At physiological pH, boric acid binds to NAD+, a coenzyme in metabolism and substrate for an enzyme in the NAD+ cADPR system of calcium signaling.

Keywords

Zinc Sugar Argon Adenocarcinoma Boron 

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References

  1. Barranco W.T. and Eckhert C.D., 2004 Boric acid inhibits human prostate cancer cell proliferation. Cancer Lett. 216: 21–9.PubMedCrossRefGoogle Scholar
  2. Cui Y., Winton M.I., Zhang Z.F., Rainey C., Marshall J., De Kernion J.B., and Eckhert C.D., 2004 Dietary boron intake and prostate cancer risk. Oncology Reports. 11, 887–892.PubMedGoogle Scholar
  3. De Flora A., Zocchi E., Guida L., Franco L., and Bruzzone S., 2004 Autocrine and Paracrine calcium signaling by the CD38/NAD+/cyclic ADP-ribose system. Ann N Y Acad. Sci. 1028, 176–191.PubMedGoogle Scholar
  4. Gallardo-Williams M.T., Chapin R.E., King P.E., Moser G.J., Goldsworthy T.L., Morrison J.P., and Maronpot R.R., 2004 Boron supplementation inhibits the growth and local expression of IGF-1 in human prostate adenocarcinoma (LNCaP) tumors in nude mice. Tox. Path. 32, 73–78.CrossRefGoogle Scholar
  5. Grill E. and Himmelbach A., 1998 ABA signal transduction. Current Opinion in Plant Biology. 1, 412–418.PubMedCrossRefGoogle Scholar
  6. Himmelbach A., Yang Y., and Grill E., 2003 Relay and control of abscisic acid signaling. Curr. Opin. Plant Biol. 6, 470–479.PubMedCrossRefGoogle Scholar
  7. Hing A.W. and Devesa S.S., 2001 Trends and patterns of prostate cancer. What do they suggest? Epidem. Rev. 23, 3–13.Google Scholar
  8. Kim D.H., Marbois B.N., Faull K.F., and Eckhert C.D., 2003 Esterification of borate with NAD+ and NADH as studied by electrospray ionization mass spectrometry and 11B NMR spectroscopy. J. Mass. Spect. 38, 632–640.CrossRefGoogle Scholar
  9. Kim D.H., Faull K.F., Norris A.J., and Eckhert C.D., 2004 Borate-nuceotide complex formation depends on charge and phosphorylation state. J. Mass. Spect. 39, 743–751.CrossRefGoogle Scholar
  10. Kim D.H., Faull K.F., Norris A.J., and Eckhert C.D. Submitted for publication.Google Scholar
  11. Nagata T., Iizumi S., Satoh K., Ooka H., Kawai J., Carninci P., Hayashizaki Y., Otoma Y., Murakami K., Matsubara K., and Kikuchi S., 2004 Comparative analysis of plant and animal calcium signal transduction element using plant full-length cDNA data. Mol. Biol. Evol. 21, 1855–1870.PubMedCrossRefGoogle Scholar
  12. Shi M. and Cheng R., 2004 Effects of zinc and boron nutrition on balsam pear (Momordica charantic) yield and quality, and polyamines, hormone, and senescence of its leaves. Ying Yong Sheng Tai Xue Bao. 15, 77–80.PubMedGoogle Scholar
  13. Stamey T.A., Caldwell M., McNeal J.E., Nolley R., Hemenez M., and Downs J., 2004 The prostate specific anigen era in the United States is over for prostate cancer: what happened in the last 29 years? J. Urol. 172, 1297–1301.PubMedCrossRefGoogle Scholar
  14. Zhang Z.-F., Winton J.I., Rainey C., and Eckhert C.D., 2001 Boron is associated with decreased risk of human prostate cancer. FASEB J. 15, A1089.CrossRefGoogle Scholar

Copyright information

© Springer 2007

Authors and Affiliations

  • Curtis Eckhert
    • 1
  • Wade Barranco
    • 1
  • Danny Kim
    • 1
  1. 1.Department of Environmental Health SciencesUniversity of CaliforniaLos AngelesUSA

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