Biology of Breast Cancer

Molecular and Pathologic Features of Ductal Neoplasia of the Breast: Racial Considerations
  • David F. Chhieng
  • Andra R. Frost
  • Lynya I. Talley
  • William E. Grizzle


Breast carcinogenesis is a multi-step process that initially is recognized histopathologically as a series of preinvasive stages (intermediate stages) leading to invasive carcinoma, and ultimately to metastatic adenocarcinoma. Histologically the preinvasive stages of breast neoplasia consist of a sequence of epithelial changes which include hyperplasia, atypical hyperplasia, and carcinoma in-situ (1, 2). All aspects of breast carcinogenesis are better characterized in ductal adenocarcinomas (the majority of breast cancers) than in lobular adenocarcinomas of the breast, which tend to have different molecular characteristics than ductal neoplasia. The subsequent discussion focuses only on ductal neoplasia of the breast.


Breast Cancer Vascular Endothelial Growth Factor Epidermal Growth Factor Receptor Breast Carcinoma African American Woman 
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Copyright information

© Springer 2006

Authors and Affiliations

  • David F. Chhieng
    • 1
  • Andra R. Frost
    • 1
  • Lynya I. Talley
    • 2
  • William E. Grizzle
    • 1
  1. 1.Department of PathologyUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.Biostatistics Unit of the Comprehensive Cancer CenterUniversity of Alabama at BirminghamBirminghamUSA

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