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The Structures of The Nitrogenase Proteins and Stabilized Complexes

  • Chapter
Catalysts for Nitrogen Fixation

Part of the book series: Nitrogen Fixation: Origins, Applications, and Research Progress ((NITR,volume 1))

Abstract

The structural characterization of the nitrogenase components has contributed, and continues to contribute, significantly to our understanding of enzymatic nitrogen reduction. Nitrogenase structure/function has been a rich area of research for several decades (reviewed in Kim and Rees, 1994; Peters et al., 1995; Howard and Rees, 1996; Rees and Howard, 1999; 2000; Rees 2002; Lawson and Smith, 2002) and the advent of detailed structures of the nitrogenase components is a relatively recent event. The structures of the Fe protein and MoFe protein from Azotobacter vinelandii appeared in the journals Science and Nature in 1992 to an enthusiastic audience (Georgiadis et al., 1992; Kim and Rees, 1992a; Kim and Rees, 1992b). These structures have had a significant impact on nitrogenase research because they (1) provide the basis for rationalizing biochemical results and (2) serve to design models for catalysis that can be tested through biochemical and biophysical studies. Subsequent to the structural characterization of the native nitrogenase components, the crystallographic analysis of defined states of the component proteins relevant to catalysis has offered significant insights to the nitrogenase research community.

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  1. Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT, 59717, USA

    P. M. C. Benton & J. W. Peters

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  1. Emeritus Fellow, John Innes Centre, Colney, Norwich, UK

    Barry E. Smith

  2. Chemistry Department, University of Sussex, Brighton, UK

    Raymond L. Richards

  3. Department of Biochemistry, Virginia Polytechnic Institute & State University, Blacksburg, USA

    William E. Newton

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Benton, P.M.C., Peters, J.W. (2004). The Structures of The Nitrogenase Proteins and Stabilized Complexes. In: Smith, B.E., Richards, R.L., Newton, W.E. (eds) Catalysts for Nitrogen Fixation. Nitrogen Fixation: Origins, Applications, and Research Progress, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-3611-8_4

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