Development of Wall Antibiotics and Bacterial Counter-Measures
The bond that cross-links two muropeptides together in the growing sacculus is a special amide bond called a tail-to-tail linkage. Such a bond is also called an endopeptide. Consequently, the transpeptidase that forms it and the hydrolyases (autolysins) that rupture it have special features that distinguish them from enzymes dealing with the usual head-to-tail peptide bonds. For antibiosis an important feature is that the conformation of the active site in the transpeptidase has a structure complimentary both to the tail-to-tail bond and to the family of four-membered β-lactam ring antibiotics.
KeywordsClavulanic Acid Methicillin Resistant Staphylococcus Aureus Turgor Pressure Diaminopimelic Acid Lactam Ring
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